Evidence map›Paper›PMID 41120497›Full record

Trial reportScientific reports2025

Linked color imaging improves polyp miss rates in total colonoscopy in a multicenter randomized back to back trial.

Ryo Shimoda, Daisuke Yamaguchi, Kazutoshi Hashiguchi, Kazuhiro Mizukami, Akira Aso, Takashi Akutagawa, Koichi Miyahara, Tetsuro Honda, Keiichi Hashiguchi, Tetsuya Ohira and 17 more

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Comparative Performance of Image-Enhanced Endoscopy for Adenoma and Sessile Serrated Lesion Detection: A Network Meta-Analysis.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Ryo ShimodaDepartment of Endoscopic Diagnostics and Therapeutics, Saga University Hospital, 5-1-1 Nabeshima, Saga, 849-8501, Japan. shimodar@cc.saga-u.ac.jp.
Daisuke YamaguchiDivision of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Kazutoshi HashiguchiInterventional Endoscopy Center, Josuikai Imamura Hospital, Tosu, Japan.
Kazuhiro MizukamiDepartment of Gastroenterology, Oita University, Yufu, Japan.
Akira AsoDepartment of Gastroenterology, Aso Clinic, Fukuoka, Japan.
Takashi AkutagawaDepartment of Endoscopic Diagnostics and Therapeutics, Saga University Hospital, 5-1-1 Nabeshima, Saga, 849-8501, Japan.
Koichi MiyaharaDepartment of Internal Medicine, Karatsu Red Cross Hospital, Karatsu, Japan.
Tetsuro HondaDepartment of Gastroenterology, Nagasaki Harbor Medical Center, Nagasaki, Japan.
Keiichi HashiguchiDepartment of Endoscopy, Nagasaki University Hospital, Nagasaki, Japan.
Tetsuya OhiraDepartment of Endoscopy, Ryukyu University Hospital, Nakagami, Japan.
Kensuke FukudaDepartment of Gastroenterology, Oita University, Yufu, Japan.
Masayuki KabayamaDepartment of Digestive and Lifestyle Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Hideaki MiyamotoDepartment of Gastroenterology and Hepatology, Kumamoto University Hospital, Kumamoto, Japan.
Ryosuke GushimaDepartment of Gastroenterology and Hepatology, Kumamoto University Hospital, Kumamoto, Japan.
Yorinobu SumidaDepartment of Gastroenterology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Sho SuzukiDepartment of Gastroenterology and Hepatology, Division of Endoscopy, Center for Digestive Disease, University of Miyazaki Hospital, Miyazaki, Japan.
Fumisato SasakiDepartment of Digestive and Lifestyle Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Naoyuki YamaguchiDepartment of Endoscopy, Nagasaki University Hospital, Nagasaki, Japan.
Tetsu KinjoDepartment of Endoscopy, Ryukyu University Hospital, Nakagami, Japan.
Tadashi MiikeDepartment of Gastroenterology and Hepatology, Division of Endoscopy, Center for Digestive Disease, University of Miyazaki Hospital, Miyazaki, Japan.
Ken OhnitaDepartment of Gastroenterology and Hepatology, Shunkaikai Inoue Hospital, Nagasaki, Japan.
Tomohiko MoriyamaInternational Medical Department, Kyushu University, Fukuoka, Japan.
Shin FujiokaDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Takashi ShonoDepartment of Gastroenterology, Kumamoto Chuo Hospital, Kumamoto, Japan.
Shimpei ShiraiDepartment of Internal Medicine, Karatsu Saiseikai Hospital, Karatsu, Japan.
Kensei OhtsuDepartment of Gastroenterology, Fukuoka University, Chikushi Hospital, Fukuoka, Japan.
Fumiaki KiyomiDepartment of Statistics and Data Center, Clinical Research Support Center Kyushu, Fukuoka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Linked color imaging (LCI) was developed to detect gastrointestinal neoplasms. The current study aimed to determine whether the use of LCI, compared with white-light imaging (WLI), can improve the miss rates of colorectal polyp. A multicenter, randomized back-to-back study was conducted in 16 Japanese endoscopy units. Patients were randomized according to examination: tandem colonoscopy with WLI followed by LCI (WLI-LCI group) and with LCI followed by WLI (LCI-WLI group). The detected polyps were evaluated according to location, size, morphology, and histopathological diagnosis. The primary outcome was polyp miss rate per patient (PMR-PP) in total colonoscopy. The secondary outcome was adenoma detection rate (ADR) during the first assessment in each group. The full analysis set comprised 327 participants, and 320 were included in either two groups. The PMR-PPs were 9.3% and 20.6% in the LCI-WLI and WLI-LCI groups, respectively. Regarding location, the PMR-PP of LCI was significantly lower than that of WLI in the transverse and descending colons and rectum. In terms of diminutive adenomas (< 5 mm), the ADR of LCI (38.2%) was significantly higher than that of WLI (29.1%). LCI was superior to WLI in terms of polyp miss rate particularly in the transverse and descending colons and rectum.

Indexed as

AdenomaColonic PolypsColonoscopyColorectal NeoplasmsAdultAgedColorFemaleHumansMaleMiddle AgedADRColonoscopyLCIMiss ratePolyps

Identifiers

PMID41120497
PMCPMC12541007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.