Evidence map›Paper›PMID 41120371›Full record

ArticleScientific reports2025

Phage host interactions reveal LPS and OmpA as receptors for two Erwinia amylovora phages.

Nassereldin Ibrahim, Jason A McAlister, Jennifer Geddes-McAlister, Antonet M Svircev, Joel T Weadge, Hany Anany

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nassereldin IbrahimAgriculture and Agri-Food Canada, Guelph Research and Development Centre, Guelph, ON, N1G 5C9, Canada.
Jason A McAlisterMolecular and Cellular Biology Department, University of Guelph, Guelph, ON, Canada.
Jennifer Geddes-McAlisterMolecular and Cellular Biology Department, University of Guelph, Guelph, ON, Canada.
Antonet M SvircevAgriculture and Agri-Food Canada, Vineland Station, ON, L0R 2E0, Canada.
Joel T WeadgeDepartment of Biology, Wilfrid Laurier University, Waterloo, ON, N2L 3C5, Canada. jweadge@wlu.ca.
Hany AnanyAgriculture and Agri-Food Canada, Guelph Research and Development Centre, Guelph, ON, N1G 5C9, Canada. hany.anany@agr.gc.ca.

Funding

Agriculture and Agrifood Canada J-002617Natural Sciences and Engineering Research Council of Canada 229971
6 · The paper itself

Abstract

Erwinia amylovora is the causative agent of fire blight. Resistance to streptomycin, the main antibiotic in fire blight management, has led to an urgent requirement to develop alternative biological control agents, such as the phage-carrier system (PCS). Previous studies have focused on the dynamic interactions between the carrier (Pantoea agglomerans), lytic phages, and the pathogen. However, crucial information about phage receptors on these hosts is still lacking. Here, a biochemical approach was used and the phage receptors of two E. amylovora phages (ϕEa21-4 and ϕEa46-1-A1) on both hosts, have been identified as LPS and OmpA on E. amylovora and OmpA only on P. agglomerans. Interestingly, this work uncovered for the first time that amylovoran is tightly attached to the LPS of E. amylovora. Confirmation of this interaction and an infection model are presented that have far reaching implications for additional PCS improvement and pathogen-host interaction details.

Indexed as

Bacterial Outer Membrane ProteinsBacteriophagesErwinia amylovoraHost-Pathogen InteractionsLipopolysaccharidesReceptors, VirusPlant DiseasesPolysaccharides, BacterialamylovoranBacterial Outer Membrane ProteinsLipopolysaccharidesOMPA outer membrane proteinsPolysaccharides, BacterialReceptors, VirusErwinia lytic phagesFire blightLipopolysaccharidesOuter membrane protein APantoea agglomeransPhage-carrier systemϕEa21-4ϕEa46-1-A1

Identifiers

PMID41120371
PMCPMC12540986

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.