ArticleScientific reports2025
Assessment of the association of high-iodine exposure in drinking water, iodine intake, and thyroid function in 3-14-year-old children.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Loss of salt iodization harmed child survival and academic achievement in Ethiopia.Nature food · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Drinking water with a high iodine content is one of the sources of iodine intake, And excessive iodine intake can affect thyroid function. This study aims to investigate the effects of long-term exposure to iodine-rich groundwater on iodine intake And thyroid function in children. We recruited a total of 3,216 children aged 3-14 years on multiple occasions from 2013 to 2023 from counties with high groundwater iodine concentrations in Shandong Province, China. We collected drinking water samples to measure water iodine concentration (WIC), spot urine samples And 24-hour (24-h) urine samples to examine the iodine status. We measured the thyroid volume and collected fasting blood and dried blood spot samples to examine the thyroid function. The median WIC of children's drinking water was 183 (IQR 70.0-362) µg/L. Within each age group, all iodine indicators, including urine iodine concentration And 24-hour urine iodine excretion, etc., and thyroid volume increased significantly with increasing water iodine concentration. The odds ratios (ORs) of the impact of drinking water with iodine concentration > 300 µg/L on hyperthyrotropinemia And goiter were 1.77 (95% confidence interval [CI], 1.20-2.62) And 4.19 (95% CI, 2.68-6.57), respectively. In children, prolonged exposure to an environment with high groundwater iodine content is associated with an increase in thyroid volume, a higher prevalence of goiter, and an increased risk of hyperthyrotropinemia. Continued efforts to reduce iodine concentration in drinking water are necessary.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.