Evidence map›Paper›PMID 41120284›Full record

ArticleCell death & disease2025

Mitochondrial calcium overload is the trigger for carbon monoxide neurotoxicity.

Plamena R Angelova, Artyom Y Baev, Sergey O Bachurin, Isabella Myers, Andrey Y Abramov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Plamena R AngelovaDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK. p.stroh@ucl.ac.uk.ORCID http://orcid.org/0000-0003-4596-9117
Artyom Y BaevLaboratory of Experimental Biophysics, Centre for Advanced Technologies, Tashkent, Uzbekistan.ORCID http://orcid.org/0000-0003-1582-5059
Sergey O BachurinInstitute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Moscow region, Russia.
Isabella MyersDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.
Andrey Y AbramovDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK. a.abramov@ucl.ac.uk.ORCID http://orcid.org/0000-0002-7646-7235

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbon monoxide is an important gasotransmitter and regulator of cell function in different tissues, including the central nervous system. However, in large doses, it is a poisonous gas that causes mortality and morbidity. Moreover, the majority of survivors of high-dose exposures develop serious neurological conditions. Here, we studied the effect of toxic concentrations of carbon monoxide released from the compound CORM-401 and its removal (re-oxygenation) on calcium signalling in primary cortical neurons and astrocytes. We found that CO induces changes in intracellular Ca

Indexed as

CalciumCarbon MonoxideMitochondriaNeuronsAnimalsAstrocytesCalcium SignalingCells, CulturedMiceRatsReactive Oxygen SpeciesCalciumCarbon MonoxideReactive Oxygen Species

Identifiers

PMID41120284
PMCPMC12541021

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.