Evidence map›Paper›PMID 41120255›Full record

ArticleCell death & disease2025

The deubiquitination enzyme USP14 promotes the tumourigenesis of gastric cancer by enhancing c-MYC nuclear translocation through deubiquitination of KPNA2.

Jia Li, Houyi Tang, Hongbo Chang, Yi Du, Liang Du, Erhu Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jia Li *Beijing Forestry University, 100083, Beijing, China.
Houyi Tang *State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing, 400716, China.
Hongbo Chang *State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing, 400716, China.
Yi DuState Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing, 400716, China.
Liang DuBeijing Forestry University, 100083, Beijing, China.
Erhu ZhaoState Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing, 400716, China. erhuzhao@126.com.ORCID http://orcid.org/0000-0001-5606-5450

Funding

Natural Science Foundation of Chongqing (Natural Science Foundation of Chongqing Municipality) CSTB2022NSCQ-MSX0631
6 · The paper itself

Abstract

The deubiquitinating enzyme USP14, which belongs to the ubiquitin-specific protease family, is highly expressed in various malignant tumors. The regulatory mechanisms in tumors are complex and diverse, encompassing a range of cellular processes such as proliferation, apoptosis, inflammation, autophagy, and drug resistance. However, the functional role of USP14 in gastric cancer remains unclear. In the current investigation, a significant upregulation of USP14 expression was observed in gastric cancer, and its overexpression was associated with an unfavorable prognosis among patients. The involvement of USP14 is indispensable for promoting the growth, motility, and infiltration of gastric cancer cells, as revealed by our findings. Further investigations revealed that USP14 interacts with KPNA2 and is responsible for deubiquitinating it by removing ubiquitin. Moreover, the deubiquitylation process mediated by USP14 was found to be critically dependent on the K48 residue of ubiquitin. The knockdown of USP14 significantly suppressed the proliferation, migration, and invasion of gastric cancer cells. This effect was attributed to the regulation of c-MYC nuclear translocation through KPNA2 deubiquitination. The findings underscore the imperative for further evaluation of the potential therapeutic significance of USP14 in gastric cancer.

Indexed as

alpha KaryopherinsCarcinogenesisCell NucleusProto-Oncogene Proteins c-mycStomach NeoplasmsUbiquitin ThiolesteraseAnimalsCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMaleUbiquitinationalpha KaryopherinsKPNA2 protein, humanMYC protein, humanProto-Oncogene Proteins c-mycUbiquitin ThiolesteraseUSP14 protein, human

Identifiers

PMID41120255
PMCPMC12540732

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.