Trial reportBMJ open2025
Effect of vitamin D supplementation during pregnancy and lactation on the development of infants born to Tanzanian women living with HIV: a secondary analysis of a randomised controlled trial.
Trial report in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02305927 (Trial of Vitamin D in HIV Progression, Birth Outcomes, and Child Health), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Trial of Vitamin D in HIV Progression, Birth Outcomes, and Child Health
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Authors and funding
9 authors.
Funding
Abstract
backgroundInfants born to pregnant women living with HIV (WLHIV) are at greater risk for morbidity and mortality and may also have poorer developmental outcomes as compared with infants who are not exposed to HIV. Nutrition interventions in pregnancy may affect developmental outcomes.
objectivesThis study evaluated the effect of maternal vitamin D supplementation on infant development outcomes.
designWe conducted a secondary analysis of a randomised, triple-blind, placebo-controlled trial of maternal vitamin D supplementation from June 2015 to October 2019.
settingAntenatal care clinics in Dar es Salaam, Tanzania.
participantsPregnant WLHIV and their offspring.
interventionsDaily 3000 IU vitamin D OUTCOME MEASURES: Infants were assessed for cognitive, language and motor development at 1 year of age with the Caregiver Reported Early Development Instruments (CREDI).
resultsA total of 2167 infants were eligible, and 1312 of them completed CREDI assessments at 1 year of age. Vitamin D supplementation had no effect on overall CREDI z-scores (standardised mean difference (SMD) 0.03, 95% CI -0.09, 0.15, p value 0.66). There was also no evidence of a difference between vitamin D and placebo groups in language (SMD 0.06, 95% CI -0.08, 0.21, p value 0.40), motor (SMD 0.02, 95% CI -0.09, 0.14, p value 0.69) or cognitive domain z-scores (SMD 0.05, 95% CI -0.08, 0.17, p 0.48).
conclusionsMaternal vitamin D supplementation during pregnancy and lactation did not affect infant development outcomes. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov identifier: NCT02305927.
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