Evidence map›Paper›PMID 41119986›Full record

ArticleBiology letters2025

Loss-of-function mutations in

Ryan Sauermann, Bronwyn Fancourt, Tim Faulkner, Hayley Shute, Dean Reid, Andrew J Pask, Charles Yakov Feigin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Loss-of-function mutations inBiology letters · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ryan SauermannSchool of BioSciences, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0009-0007-1754-8207
Bronwyn FancourtSchool of Environmental and Rural Science, University of New England, Armidale, New South Wales, Australia.ORCID 0000-0003-2969-1530
Tim FaulknerAustralian Reptile Park & Aussie Ark, Somersby, New South Wales, Australia.
Hayley ShuteAustralian Reptile Park & Aussie Ark, Somersby, New South Wales, Australia.
Dean ReidAustralian Reptile Park & Aussie Ark, Somersby, New South Wales, Australia.
Andrew J PaskSchool of BioSciences, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-1900-2263
Charles Yakov FeiginSchool of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, Victoria, Australia.ORCID 0000-0003-4981-5254

Funding

Revive & Restore Wild GenomesWilson Family Trust
6 · The paper itself

Abstract

Pigmentation in mammalian hair follicles is governed in part by interactions between agouti signalling protein (ASIP) and the melanocortin 1 receptor (MC1R). The most common coat colours in mammals result from alternating bands of dark eumelanin and light phaeomelanin within individual hair shafts. However, coats dominated by a single melanin have arisen several times. Here, we examine the genetic basis of two instances in marsupials: a melanistic morph of the eastern quoll (

Indexed as

Agouti Signaling ProteinHair ColorLoss of Function MutationMarsupialiaReceptor, Melanocortin, Type 1AnimalsAgouti Signaling ProteinReceptor, Melanocortin, Type 1coat colourconvergent evolutiongenomicsloss-of-functionmarsupial molemelanismpigmentationquollTasmanian devilxanthism

Identifiers

PMID41119986
PMCPMC12539951

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.