Evidence map›Paper›PMID 41118665›Full record

ArticleJournal of the American Chemical Society2025

Mahmoud M AbdElwakil, Jeffrey Ni, Summer Ramsay-Burrough, Paul Joshua Hurst, Rebecca L McClellan, Samuel R Khasnavis, Yuan Jia, Sehar R Masud, Timothy R Blake, Adrienne Sallets and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Mahmoud M AbdElwakilDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID 0000-0002-2450-6669
Jeffrey NiDepartment of Pediatrics, Division of Pulmonary Medicine, Stanford University School of Medicine, Stanford, California 94305, United States.
Summer Ramsay-BurroughDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID 0000-0002-0575-4835
Paul Joshua HurstDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID 0000-0002-1826-2549
Rebecca L McClellanDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Samuel R KhasnavisDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Yuan JiaDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Sehar R MasudDepartment of Pediatrics, Division of Pulmonary Medicine, Stanford University School of Medicine, Stanford, California 94305, United States.
Timothy R BlakeDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Adrienne SalletsDivision of Oncology, Department of Medicine, Stanford Cancer Institute, Stanford University, Stanford, California 94305, United States.
Ole A W HaabethDivision of Oncology, Department of Medicine, Stanford Cancer Institute, Stanford University, Stanford, California 94305, United States.
Idit Sagiv-BarfiDivision of Oncology, Department of Medicine, Stanford Cancer Institute, Stanford University, Stanford, California 94305, United States.
Debra K CzerwinskiDivision of Oncology, Department of Medicine, Stanford Cancer Institute, Stanford University, Stanford, California 94305, United States.
Marco Herrera-BarreraInstitute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, United States.
Ronald LevyDivision of Oncology, Department of Medicine, Stanford Cancer Institute, Stanford University, Stanford, California 94305, United States.
Paul A WenderDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID 0000-0001-6319-2829
Maya E KumarDepartment of Pediatrics, Division of Pulmonary Medicine, Stanford University School of Medicine, Stanford, California 94305, United States.
Robert M WaymouthDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID 0000-0001-9862-9509

Funding

SYNTHETIC STUDIES RELATED TO CANCER RESEARCH/TREATMENTR01CA031845 · NCI · STANFORD UNIVERSITY · PI PAUL Anthony WENDER · 1985 to 2026
$6.9M
Synthetic Studies Related to Cancer Research/TreatmentR37CA031845 · NCI · STANFORD UNIVERSITY · PI WENDER, PAUL ANTHONY · 2006 to 2015
$4.5M
NCI NIH HHS R01 CA031845NCI NIH HHS R37 CA031845
6 · The paper itself

Abstract

Endothelial cells (ECs) comprise the pulmonary vascular bed and play a significant role in health and diseases. Consequently, the EC niche represents an attractive therapeutic target for treating a wide range of pulmonary vascular diseases. We have identified a new class of dicationic charge-altering releasable transporters. These single-component transporters selectively deliver mRNA to the lung upon intravenous administration without the use of a targeting ligand. Significantly, the number and spatial array of cationic charges within the repeating units of the CART polymer are found to control both mRNA delivery efficacy and tissue tropism. High-resolution imaging revealed efficient mRNA delivery to endothelial cells in pulmonary arteries, veins, and capillaries. The selective lung tropism of these new CARTs, coupled with the efficient and tunable synthesis of this new family of CART amphiphiles, represents an enabling platform for research and clinical applications.

Indexed as

Endothelium, VascularLungRNA, MessengerAnimalsHumansMiceRNA, Messenger

Identifiers

PMID41118665
PMCPMC13186261

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.