Evidence map›Paper›PMID 41118507›Full record

ArticleNucleic acids research2026

riboCIRC v2.0: an expanded resource for translatable CircRNAs.

Yunhao Xu, Lei Yang, Yuewen Tang, Yan Wang, Hongwei Wang

Abstract read
In one paragraph

Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Overview of circular RNA databases and other resources.Nature reviews. Molecular cell biology · 2026
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yunhao XuState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China.
Lei YangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China.
Yuewen TangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China.
Yan WangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China.
Hongwei WangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China.ORCID 0000-0003-3581-8892

Funding

Guangdong Basic and Applied Basic Research Foundation 2024A1515010103Guangzhou Science and Technology Program 2024A03J0158National Natural Science Foundation of China 32270700
6 · The paper itself

Abstract

riboCIRC (http://www.ribocirc.com) is a translatome data-oriented database dedicated to cataloging translatable circRNAs and their encoded peptides across six model species, including Homo sapiens, Mus musculus, Rattus norvegicus, Caenorhabditis elegans, Drosophila melanogaster, and Danio rerio. Here, we present riboCIRC v2.0, a major update featuring expanded content and enhanced functionality to facilitate and accelerate research into circRNA translation and function characterization. Key improvements include (i) expanded data coverage: now documenting 5212 computationally predicted translatable circRNAs and 7563 predicted finite ORF-encoded peptides, representing a substantial increase from the initial release (2247 and 2234 entries, respectively); (ii) enhanced evidence integration: incorporation of new evidence layers supporting translation of circRNAs, including RNA editing sites and RBP interactions, supplementing existing evidence from ribosome profiling, mass spectrometry, IRES elements, and m6A modifications; (iii) comprehensive peptide annotation: systematic in silico characterization of finite ORF-encoded peptides, detailing their physicochemical properties, predicted structures, and potential functions; and (iv) optimized user interface: improved navigation and dedicated modules for streamlined data exploration, retrieval, and visualization. Collectively, these enhancements establish riboCIRC v2.0 as a more powerful resource for investigating the functional roles of translatable circRNAs and their products across diverse biological systems.

Indexed as

Databases, GeneticDatabases, Nucleic AcidProtein BiosynthesisRNA, CircularAnimalsCaenorhabditis elegansComputational BiologyDrosophila melanogasterHumansMiceOpen Reading FramesPeptidesRatsRibosomesSoftwareUser-Computer InterfacePeptidesRNA, Circular

Identifiers

PMID41118507
PMCPMC12807610

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.