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Abnormally expressed lncRNAs as potential biomarkers for schizophrenia and positive symptoms.
Article in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
ObjectiveAlthough numerous studies have reported on the relationship between abnormal expression of long non-coding RNAs (lncRNAs) and schizophrenia (SZ), few have focused on aberrant lncRNAs as potential clinical biomarkers for diagnosing SZ and their association with psychiatric symptoms.MethodsTo investigate the diagnostic value of lncRNAs as specific biomarkers in the plasma of patients with SZ and to explore the relationship between the expression levels of aberrant lncRNAs and psychiatric symptoms, we examined the expression levels of ten significantly aberrant lncRNAs (ENST00000394742.3, TCONS_l2_00025502, NONHSAT098126, NONHSAT089447, ENST00000563823.2, NONHSAT021545, NONHSAT041499, ENST00000521622.1, TCONS_l2_00021339, NONHSAT1047781). The ten significantly aberrant lncRNAs were analyzed in plasma samples from 96 SZ patients and 48 healthy controls using quantitative real-time reverse transcription polymerase chain reaction. Additionally, the Positive and Negative Syndrome Scale and the Global Assessment Scale (GAS) were utilized to assess the psychiatric symptoms of the SZ patients.ResultsThe results demonstrated that a panel of lncRNAs consisting of NONHSAT089447, NONHSAT021545, and NONHSAT041499 exhibited significant upregulation and combined diagnostic value for SZ (AUC = 0.689,
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