Evidence map›Paper›PMID 41118343›Full record

ReviewPLoS biology2025

Disease-associated microglia in neurodegenerative diseases: Friend or foe?

Yi-Hsuan Cheng, Margaret S Ho

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in PLoS biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

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  12. Alzheimer's Disease Risk AllelebioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yi-Hsuan ChengInstitute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Margaret S HoInstitute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan.ORCID 0000-0002-2387-7564

Funding

2030 Cross-Generation International Outstanding Young Scholars Program National Science and Technology Council TaiwanBrain Research Center National Yang Ming Chiao Tung UniversityNational Natural Science Foundation of ChinaNational Yang Ming Chiao Tung University
6 · The paper itself

Abstract

Recent advances in single-cell transcriptomics have led to the identification of disease-associated microglia (DAM) as a distinct, conserved microglia state associated with mouse models of Alzheimer's disease (AD) and amyotrophic lateral sclerosis, and with aging. DAM are characterized by downregulation of homeostatic genes and upregulation of lipid metabolism and phagocytosis genes, including key risk factors for AD in humans. Although characterized in models of AD, whether DAM acts as universal sensor across all neurodegenerative diseases remains unknown. This Essay discusses the dynamics, origins, and therapeutic potential of DAM in neurodegeneration, alongside evidence supporting a protective role for them in regulating disease processes.

Indexed as

MicrogliaNeurodegenerative DiseasesAgingAlzheimer DiseaseAmyotrophic Lateral SclerosisAnimalsDisease Models, AnimalHumansLipid MetabolismMicePhagocytosisTranscriptome

Identifiers

PMID41118343
PMCPMC12539720

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.