Evidence map›Paper›PMID 41118320›Full record

ArticleAntimicrobial agents and chemotherapy2025

Variability in intrinsic drug tolerance in

Valerie F A March, Michaela Zwyer, Chloé Loiseau, Daniela Brites, Galo A Goig, Selim Bouaouina, Anna Doetsch, Miriam Reinhard, Sevda Kalkan, Sebastien Gagneux and 1 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Within-host evolution of drug tolerance inJAC-antimicrobial resistance · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Valerie F A MarchSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Michaela ZwyerSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Chloé LoiseauSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Daniela BritesSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Galo A GoigSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Selim BouaouinaSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Anna DoetschSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Miriam ReinhardSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Sevda KalkanSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Sebastien GagneuxSwiss Tropical and Public Health Institute, Allschwil, Switzerland.ORCID 0000-0001-7783-9048
Sonia BorrellSwiss Tropical and Public Health Institute, Allschwil, Switzerland.ORCID 0000-0001-6661-6957

Funding

European Research Council 883582-ECOEVODRTBSwiss National Science Foundation 320030-227432Swiss National Science Foundation 320030L-231163Swiss National Science Foundation CRSII5_213514
6 · The paper itself

Abstract

Drug tolerance allows bacteria to survive extended exposure to bactericidal drugs and is thought to play a role in drug resistance evolution. In

Indexed as

Antitubercular AgentsMycobacterium tuberculosisCell WallDiarylquinolinesDrug Resistance, Multiple, BacterialHumansMicrobial Sensitivity TestsMutationPhylogenyRifampinTuberculosis, Multidrug-ResistantAntitubercular AgentsbedaquilineDiarylquinolinesRifampinbedaquilinedrug tolerancegenetic diversityMycobacterium tuberculosisrifampicin

Identifiers

PMID41118320
PMCPMC12691649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.