Evidence map›Paper›PMID 41118311›Full record

ArticleeLife2025

The capsule and genetic background, rather than specific individual loci, strongly influence in vitro pneumococcal growth kinetics.

Chrispin Chaguza, Daan W Arends, Stephanie W Lo, Indri Hapsari Putri, Anna York, John A Lees, Anne L Wyllie, Daniel M Weinberger, Stephen D Bentley, Marien I de Jonge and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chrispin ChaguzaDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, United States.ORCID https://orcid.org/0000-0002-2108-1757
Daan W ArendsLaboratory of Medical Immunology, Radboud Institute of Molecular Life Sciences, Radboudumc Center for Infectious Diseases, Radboudumc, Nijmegen, Netherlands.
Stephanie W LoParasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Indri Hapsari PutriLaboratory of Medical Immunology, Radboud Institute of Molecular Life Sciences, Radboudumc Center for Infectious Diseases, Radboudumc, Nijmegen, Netherlands.
Anna YorkDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, United States.
John A LeesEuropean Molecular Biology Laboratory-European Bioinformatics Institute, Cambridge, United Kingdom.
Anne L WyllieDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, United States.ORCID https://orcid.org/0000-0001-6015-0279
Daniel M WeinbergerDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, United States.ORCID https://orcid.org/0000-0003-1178-8086
Stephen D BentleyParasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Marien I de Jonge *Laboratory of Medical Immunology, Radboud Institute of Molecular Life Sciences, Radboudumc Center for Infectious Diseases, Radboudumc, Nijmegen, Netherlands.
Amelieke J H Cremers *Laboratory of Medical Immunology, Radboud Institute of Molecular Life Sciences, Radboudumc Center for Infectious Diseases, Radboudumc, Nijmegen, Netherlands.ORCID https://orcid.org/0000-0003-4704-4978

Funding

Gates Foundation OPP1034556JPI-AMR-ZonMW JPIAMR2019-087Swiss National Science Foundation TMPFP3_209768Wellcome TrustWellcome Trust 10.35802/206194
6 · The paper itself

Abstract

Bacterial growth characteristics intrinsic to each strain can impact and influence gene expression, antibiotic susceptibility, and disease pathogenesis. However, little is known about specific genomic variations that influence these bacterial growth features. Here, we investigate the impact of

Indexed as

Bacterial CapsulesStreptococcus pneumoniaeGenetic LociGenome-Wide Association StudyHumansKineticsPhylogenySerogroupbacterial growthgenetic backgroundgenome-wide association studyinfectious diseasemicrobiologyserotypeStreptococcus pneumoniaewhole-genome sequencing

Identifiers

PMID41118311
PMCPMC12539807

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.