Evidence map›Paper›PMID 41118218›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

HIF2α negatively regulates MYCN protein levels and promotes a low-risk noradrenergic phenotype in neuroblastoma.

Juan Yuan, Subhamita Maitra, Eirini Antoniou, Jiacheng Zhu, Wenyu Li, Ilknur Safak Demirel, Kostantinos Toskas, Iria Laura Martinez, Lacin Ozcimen, Henrik Lindehell and 6 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Juan Yuan *Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm 171 77, Sweden.
Subhamita Maitra *Department of Molecular Biology, Umeå University, Umeå 901 87, Sweden.
Eirini AntoniouDepartment of Molecular Biology, Umeå University, Umeå 901 87, Sweden.ORCID 0000-0002-3616-9049
Jiacheng ZhuDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm 171 77, Sweden.
Wenyu LiDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm 171 77, Sweden.
Ilknur Safak DemirelDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm 171 65, Sweden.
Kostantinos ToskasDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm 171 77, Sweden.
Iria Laura MartinezDepartment of Molecular Biology, Umeå University, Umeå 901 87, Sweden.ORCID 0009-0002-2219-5366
Lacin OzcimenDepartment of Molecular Biology, Umeå University, Umeå 901 87, Sweden.ORCID 0009-0005-8881-4547
Henrik LindehellDepartment of Molecular Biology, Umeå University, Umeå 901 87, Sweden.ORCID 0000-0003-1195-2341
Jonas MuhrDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm 171 77, Sweden.ORCID 0000-0003-0704-0788
Jakob StenmanDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm 171 65, Sweden.
Per KognerDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm 171 65, Sweden.ORCID 0000-0002-2202-9694
Oscar C Bedoya-ReinaDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm 171 65, Sweden.ORCID 0009-0001-1703-2258
Susanne SchlisioDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm 171 77, Sweden.ORCID 0000-0002-2605-3771
Johan HolmbergDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm 171 77, Sweden.ORCID 0000-0002-3018-001X

Funding

Barncancerfonden (Swedish Childhood Cancer Foundation) PR2023-0013Cancerfonden (Swedish Cancer Society) 23 3144 PjVetenskapsrådet (VR) VR2022-000731
6 · The paper itself

Abstract

The role of HIF2α, encoded by

Indexed as

Adrenergic NeuronsBasic Helix-Loop-Helix ProteinsNeuroblastomaN-Myc Proto-Oncogene ProteinAdrenal MedullaAnimalsCell DifferentiationCell Line, TumorCell ProliferationEndothelial PAS Domain-Containing Protein 1Gene Expression Regulation, NeoplasticHumansMicePhenotypeBasic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1MYCN protein, humanN-Myc Proto-Oncogene ProteinHIF2αMYCNneuroblastomanoradrenergic differentiationtumor suppression

Identifiers

PMID41118218
PMCPMC12582314

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.