Evidence map›Paper›PMID 41118161›Full record

ArticleJAMA network open2025

Changes in Colorectal Cancer Screening Modalities Among Insured Individuals.

Sunny Siddique, Rong Wang, Folasade P May, Laura V M Baum, Cary P Gross, Xiaomei Ma

Abstract read
In one paragraph

Article in JAMA network open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sunny SiddiqueDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.
Rong WangDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.
Folasade P MayDivision of Digestive Diseases, University of California Los Angeles Devid Geffen School of Medicine, Los Angeles.
Laura V M BaumDepartment of Medicine, Medical Oncology, Yale School of Medicine, New Haven, Connecticut.
Cary P GrossDepartment of Medicine, General Medicine, Yale School of Medicine, New Haven, Connecticut.
Xiaomei MaDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.

Funding

The Yale Cancer Prevention and Control Training ProgramT32CA250803 · NCI · YALE UNIVERSITY · PI Melinda L Irwin, Xiaomei Ma · 2020 to 2026
$2.3M
NCI NIH HHS T32 CA250803
6 · The paper itself

Abstract

Importance: Several colorectal cancer (CRC) screening modalities (eg, colonoscopy, stool-based tests) are currently available. Yet, recent national patterns in screening using these modalities and potential differences across sociodemographic groups remain unclear. Objective: To evaluate possible changes in the use of different CRC screening modalities among average-risk individuals aged 50 to 75 years in the US. Design, Setting, and Participants: This retrospective cohort study used deidentified claims data from 2017 to 2024. Participants included a dynamic cohort of commercially insured Blue Cross Blue Shield beneficiaries. Data were analyzed from May 1 to June 30, 2025. Exposures: Invasive and noninvasive CRC screening modalities. Main Outcomes and Measures: Changes in screening modality use were compared between the periods preceding the onset of the COVID-19 pandemic (ie, preonset: January 1, 2017, to February 28, 2020) and following the onset of the pandemic (ie, postonset: July 1, 2020, to December 31, 2024). Changes in screening by modality were also evaluated using autoregressive integrated moving average models, adjusting for temporal autocorrelation and seasonality. Results: In this retrospective cohort study of 24 973 642 distinct beneficiaries (mean [SD] age, 57.36 [4.27] years; 12 789 413 female [51.21%]), the use of colonoscopy (mean [SD], 1.29% [0.09%] to 1.14% [0.07%]; P < .001) and fecal immunochemical test (FIT) decreased between the 2 periods (mean [SD], 0.54% [0.03%] to 0.38% [0.07%]; P < .001). However, stool DNA test use increased (mean [SD], 0.19% [0.13%] to 0.61% [0.16%]; P < .001). Males had higher use of colonoscopy than females (mean [SD], 1.21% [0.07%] vs 1.07% [0.07%]; P < .001), whereas females had higher use of stool DNA test than males (mean [SD], 0.68% [0.16%] vs 0.55% [0.15%]; P < .001) and FIT (mean [SD], 0.43% [0.08%] vs 0.33% [0.05%]; P < .001). Areas with socioeconomic status (SES) in the top 20% had higher use of colonoscopy compared with areas where a marker of SES was in the bottom 20% (mean [SD], 1.37% [0.09%] vs 0.91% [0.06%]; P < .001) and stool DNA test (mean [SD], 0.65% [0.17%] vs 0.48% [0.13%]; P < .001) and lower use of FIT (mean [SD], 0.36% [0.09%] vs 0.48% [0.06%]; P < .001). Metropolitan area residents, compared with nonmetropolitan area residents, more frequently underwent colonoscopy (mean [SD], 1.18% [0.08%] vs 0.97% [0.06%]; P < .001) and FIT (mean [SD], 0.41% [0.08%] vs 0.25% [0.04%]; P < .001); however, their use of stool DNA test were similar (mean [SD], 0.61% [0.16%] vs 0.64% [0.16%]; P = .51). Conclusions and Relevance: Among privately insured individuals, the use of colonoscopy and FIT decreased after the COVID-19 pandemic while stool DNA test use increased, with differences by sex, area-level SES, and metropolitan area residence.

Indexed as

Colorectal NeoplasmsEarly Detection of CancerMass ScreeningAgedColonoscopyCOVID-19FemaleHumansMaleMiddle AgedOccult BloodRetrospective StudiesSARS-CoV-2United States

Identifiers

PMID41118161
PMCPMC12541536

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.