ArticleInternational urology and nephrology2026
Leptospirosis-associated acute kidney injury in Odisha, India.
Article in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND AND
objectiveLeptospirosis, a zoonotic disease, is a major cause of acute kidney injury (AKI) in tropical regions, with outbreaks frequently reported across India. Given the limited local literature, this study aimed to explore the incidence of leptospirosis-associated AKI (LAKI) in Odisha, an Eastern Indian state.
methodsThis hospital-based study was conducted from July 2020 to December 2022. Patients with acute febrile illness or a history of acute fever impacting normal kidney function who were admitted to two major tertiary care hospitals in Odisha were enrolled in this study. A pre-tested questionnaire gathered demographic and clinical data. Leptospirosis was detected using Lepto-IgM ELISA. Statistical analysis involved t-tests, chi-square tests, and one-way ANOVA, with significance set at p < 0.05 or p < 0.01.
resultsOf the total 199 AKI patients included in the study, leptospirosis was confirmed in 57 (28.6%) cases, primarily affecting males (66.7%). The majority of LAKI patients were agricultural workers and resided in rural areas. Of the total LAKI patients, 8.8% had jaundice, and according to the KDIGO criteria, 77.2% were placed in stage 3 of AKI. The mortality rate was 15.8%. Statistically significant differences were observed in several laboratory parameters, including haemoglobin, platelet count, albumin, serum bilirubin, serum creatinine, serum urea nitrogen, serum alanine transaminase, and serum aspartate aminotransferase (all p < 0.00001).
interpretationThe study found a high prevalence of LAKI, accompanied by a high case fatality rate. An extensive study is necessary to determine the exact burden of LAKI in Odisha to design an appropriate control strategy.
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