Evidence map›Paper›PMID 41118084›Full record

ArticleDiscover oncology2025

Association of antipsychotic drug target genes and risk of lung cancer: a Mendelian randomization study.

Jun Xiang, Guangming Xiang, Ming Zhan, Lingyun Zhang, Huaqian Zeng, Xinyu Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jun XiangFirst College of Clinical Medical Science, China Three Gorges University, Yichang, 443003, China.
Guangming XiangFirst College of Clinical Medical Science, China Three Gorges University, Yichang, 443003, China.
Ming ZhanFirst College of Clinical Medical Science, China Three Gorges University, Yichang, 443003, China.
Lingyun ZhangFirst College of Clinical Medical Science, China Three Gorges University, Yichang, 443003, China.
Huaqian ZengDepartment of Pharmacy, Yichang Special Care Hospital, Yichang, 443005, China.
Xinyu SongFirst College of Clinical Medical Science, China Three Gorges University, Yichang, 443003, China. sxy1421@163.com.

Funding

The demonstration project of Technological Innovation of Hubei Province 2022BCE031Yichang Medical and Health Research Project A22-2-003
6 · The paper itself

Abstract

backgroundAntipsychotic drugs are associated with various tumors, but their causal relationship with lung cancer risk remains unclear. We aimed to investigate this association using Mendelian randomization (MR) analyses.

methodsWe performed summary-data-based MR (SMR) using blood-derived expression quantitative trait loci (eQTL) and two sample-MR using single nucleotide polymorphism (SNP) of antipsychotic drug target genes. Colocalization analysis was performed with cis-eQTLs, and sensitivity analyses included the Heterogeneity in dependent instruments (HEIDI) test and Multi-SNP-based SMR.

resultsSMR showed that higher DRD4 expression was associated with lower lung cancer risk (P

conclusionThese findings provide insights into the potential oncologic implications of antipsychotic drug use and may inform clinical management.

Indexed as

Antipsychotic drugsColocalization analysisGenetic instrumentsLung cancersMendelian randomization

Identifiers

PMID41118084
PMCPMC12540951

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.