Evidence map›Paper›PMID 41118055›Full record

ArticleEJNMMI research2025

In vivo gastrin releasing peptide receptor expression in SDH deficient wild-type gastrointestinal stromal tumours (GIST): potential for theranostic applications.

David G E Hulse, Ines Harper, Fung Tan, Daniel Gillett, Victoria Warnes, Mary McLean, Pascal Wodtke, Ferdia Gallagher, Eamonn R Maher, Olivier Giger and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

David G E HulseDepartment of Radiology, University of Cambridge, Cambridge, UK.
Ines HarperDepartment of Nuclear Medicine, Cambridge University Hospitals Foundation Trust, Cambridge, UK.
Fung TanDepartment of Nuclear Medicine, Cambridge University Hospitals Foundation Trust, Cambridge, UK.
Daniel GillettDepartment of Nuclear Medicine, Cambridge University Hospitals Foundation Trust, Cambridge, UK.
Victoria WarnesDepartment of Nuclear Medicine, Cambridge University Hospitals Foundation Trust, Cambridge, UK.
Mary McLeanDepartment of Radiology, University of Cambridge, Cambridge, UK.
Pascal WodtkeDepartment of Radiology, University of Cambridge, Cambridge, UK.
Ferdia GallagherDepartment of Radiology, University of Cambridge, Cambridge, UK.
Eamonn R MaherDepartment of Medical Genetics, University of Cambridge, Cambridge, UK.
Olivier GigerCellular Pathology Department, St Marks Hospital, London North West University Healthcare NHS Trust, London, UK.
Ramesh BulusuDepartment of Medical Oncology, Cambridge University Hospitals Foundation Trust, Cambridge, UK.
Luigi AlojDepartment of Radiology, University of Cambridge, Cambridge, UK. la398@medschl.cam.ac.uk.ORCID https://orcid.org/0000-0002-7452-4961
Ruth T CaseyDepartment of Medical Genetics, University of Cambridge, Cambridge, UK. rc674@medschl.cam.ac.uk.ORCID https://orcid.org/0000-0003-4058-3135

Funding

Advanced Accelerator Applications, a Novartis company, has provided funding and supply of kits for radiopharmaceutical preparation of [68Ga]NeoB. Advanced Accelerator Applications, a Novartis company, has provided funding and supply of kits for radiopharmaceutical preparation of [68Ga]NeoB.Cancer Research UK Cambridge Institute, University of Cambridge C9685/A25117NIHR Cambridge Biomedical Research Centre NIHR203312
6 · The paper itself

Abstract

backgroundSuccinate dehydrogenase (SDH) deficient wild-type Gastrointestinal Stromal Tumours (wtGIST) are a rare GIST subtype with limited treatment options. Gallium-68 labelled Gastrin Releasing Peptide Receptor (GRPR) antagonist NeoB has shown promise in PET imaging for multiple primary malignancies. This investigation sought to assess the biodistribution of [

resultsTwelve patients with histologically confirmed metastatic wtGIST were enrolled. [

conclusionsThe majority of wtGIST patients in this small cohort show lesions with intense [ CLINICAL TRIAL NUMBER: Not applicable.

Identifiers

PMID41118055
PMCPMC12540235

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.