Trial reportInternational ophthalmology2025
The effects of topical nepafenac on pupillary dynamics in early postoperative period following uneventful cataract surgery: a prospective randomized study.
Trial report in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the post operative pupillary dynamics under different lighting conditions and evaluate the effect of topical non-steroid anti-inflammatory drugs (NSAIDs) in early postoperative inflammation following an uneventful cataract surgery.
methodsA prospective, randomized clinical study. Fifty eyes of 50 patients underwent uneventful conventional cataract surgery were randomized (1:1) to receive postoperative moxifloxacin 0.5% and dexamethasone 0.1% only (NSAID (-) group) or combined with nepafenac 0.1% (NSAID ( +) group). Pupillography was performed under scotopic, mesopic and photopic conditions before the surgery, at postoperative 1st week and 1st month. Clinical parameters and cumulative dissipated energy (CDE) during phacoemulsification were recorded.
resultsTwenty-six women and 24 men were studied. A significant decrease was found in scotopic pupil diameter (PD) in NSAID (-) group, that this decrease was 12.9% and 7.54% at postoperative 1st week and 1st month (p = 0.003, p = 0.045, respectively). However, no significant change was calculated in NSAID ( +) group. Also, a significant decrease of 5.3% was found in mesopic PD at postoperative 1st week in NSAID (-) group (p = 0.016). Under photopic conditions, no difference was noted neither in NSAID (-) nor in NSAID ( +) group during the follow up (All p > 0.05). The mean CDE value was insignificant between two groups (9.07 ± 5.21, 9.50 ± 5.40, respectively) (p = 0.398).
conclusionAdjunctive topical Nepafenac 0.1% use might attenuate early postoperative scotopic and mesopic pupil constriction following an uneventful cataract surgery. Although the effect appears most pronounced during the first postoperative week, this short-term benefit may be clinically relevant, particularly for patients with premium intraocular lens or those who rely heavily on low-light vision.
Indexed as
Identifiers
41117999What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.