Evidence map›Paper›PMID 41117985›Full record

ArticleEuropean journal of pediatrics2025

Positive end-expiratory pressure impact on cardiac output and cerebral hemodynamics in newborns.

Masashi Zuiki, Akihiro Managi, Kazunori Watanabe, Norihiro Iwata, Rika Mitsuno, Madoka Konishi, Akio Yamano, Eisuke Ichise, Kanae Hashiguchi, Tatsuji Hasegawa and 1 more

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Article in European journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Masashi ZuikiDepartment of Paediatrics, Kyoto Prefectural University of Medicine, Kamigyoku, Kyoto, Japan. zuiki@koto.kpu-m.ac.jp.
Akihiro ManagiDepartment of Paediatrics, Kyoto Prefectural University of Medicine, Kamigyoku, Kyoto, Japan.
Kazunori WatanabeDepartment of Paediatrics, Kyoto Prefectural University of Medicine, Kamigyoku, Kyoto, Japan.
Norihiro IwataDepartment of Paediatrics, Kyoto Prefectural University of Medicine, Kamigyoku, Kyoto, Japan.
Rika MitsunoDepartment of Paediatrics, Kyoto Prefectural University of Medicine, Kamigyoku, Kyoto, Japan.
Madoka KonishiDepartment of Paediatrics, Kyoto Prefectural University of Medicine, Kamigyoku, Kyoto, Japan.
Akio YamanoDepartment of Paediatrics, Kyoto Prefectural University of Medicine, Kamigyoku, Kyoto, Japan.
Eisuke IchiseDepartment of Paediatrics, Kyoto Prefectural University of Medicine, Kamigyoku, Kyoto, Japan.
Kanae HashiguchiDepartment of Paediatrics, Kyoto Prefectural University of Medicine, Kamigyoku, Kyoto, Japan.
Tatsuji HasegawaDepartment of Paediatrics, Kyoto Prefectural University of Medicine, Kamigyoku, Kyoto, Japan.
Tomoko IeharaDepartment of Paediatrics, Kyoto Prefectural University of Medicine, Kamigyoku, Kyoto, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to clarify the extrapulmonary effects of positive end-expiratory pressure (PEEP) in neonates using noninvasive monitoring techniques to monitor cardiac output (CO) and cerebral hemodynamics. This was a prospective, nonrandomized, consecutive enrollment, single-centre study. Newborns weighing ≥ 1,000 g admitted to the neonatal intensive care unit for invasive mechanical ventilation from April 2023 to December 2024 were included. PEEP levels increased sequentially to 5 cm H

conclusionPEEP levels used in this study reduced CO without affecting cerebral perfusion. Although clinically used PEEP levels have minimal impact on cerebral perfusion in newborns, high PEEP may decrease blood circulation to organs outside the brain. WHAT IS KNOWN: •Setting an appropriate positive end-expiratory pressure (PEEP) is a key component of ventilator management in newborns. PEEP influence extrapulmonary functions, including cardiac output (CO) and cerebral hemodynamics. However, limited research has explored these extrapulmonary effects of PEEP in neonates. WHAT IS NEW: • The PEEP levels used in this study reduced CO without affecting cerebral perfusion in newborns. Clinically used PEEP levels have minimal impact on cerebral perfusion in newborns. However, high PEEP may decrease blood circulation to organs outside the brain.

Indexed as

Cardiac OutputCerebrovascular CirculationHemodynamicsPositive-Pressure RespirationFemaleHumansInfant, NewbornInfant, PrematureIntensive Care Units, NeonatalMaleMonitoring, PhysiologicProspective StudiesSpectroscopy, Near-InfraredCardiac outputNear-infrared spectroscopyNeonatal intensive care unitsPositive pressure respirationStroke volume

Identifiers

PMID41117985

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.