Observational studyInternational ophthalmology2025
Vascular reaction parameters correlate with severe nerve fibre thickness loss and visual field defects in glaucoma.
Observational study in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Advancing Retinal Vessel Analysis: Reproducibility of Myogenic Constriction and Assessment of Regulatory Capacity.Translational vision science & technology · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
purposeVascular risk factors and ocular perfusion abnormalities are key elements in the pathogenesis of glaucoma. The retinal vessel analyser (RVA; IMEDOS Systems, Germany) enables non-invasive assessment of dynamic changes in retinal vessel diameters in response to light stimulation. In this pilot study, we explored whether parameters of vascular regulation correlate with visual field defects and retinal nerve fibre layer (RNFL) thickness (SD-OCT, Spectralis) in glaucoma patients.
methodsA cross-sectional observational study was conducted involving 34 eyes from 34 patients with advanced visual field defects associated with primary open-angle glaucoma (POAG). Following pharmacological pupil dilation, RVA measurements were performed according to a standardised protocol including stimulation with monochromatic flicker light. The resulting vascular response parameters were then analysed for correlations with both global and hemispheric visual field defects, as well as global and corresponding hemispheric RNFL thickness.
resultsMaximal venous dilatation (r = 0.39, p < 0.02) as well as arterial (r = 0.41, p < 0.01) and venous amplitude of vessel reaction (r = 0.31, p < 0.04) were significantly correlated to overall visual field defect mean deviation (MD). Venous maximal dilatation (r = 0.47, p < 0.004), the amplitude of vessel reaction (r = 0.37, p < 0.01) and the amplitude of arterial vessel reaction (r = 0.33, p < 0.02) were significantly correlated to overall RNFL thickness. Time until maximal dilatation in the arteries was significantly correlated to the corresponding hemispheric RNFL thickness (r = - 0.43, p < 0.007).
conclusionVascular reaction parameters show significant correlations with structural and functional impairment in advanced stages of glaucoma. These findings support the hypothesis that disturbed ocular blood flow and autoregulatory mechanisms may contribute to disease severity.
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