Beta to low-gamma rhythmic brain stimulation over primary motor cortex and supplementary motor area differentially modulates oscillatory neural drives during gait.

Ryosuke Kitatani, Shiori Hirano, Runa Sorimachi, Rina Numata, Haruki Hoshi, Naofumi Otsuru, Sumiya Shibata, Hideaki Onishi

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Article in Experimental brain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Ryosuke KitataniDepartment of Physical Therapy, Niigata University of Health and Welfare, 1398, Shimami‑cho, Kita‑ku, Niigata, 950‑3198, Japan. ryosuke-kitatani@nuhw.ac.jp.ORCID http://orcid.org/0000-0001-6580-7946

Shiori HiranoDepartment of Physical Therapy, Niigata University of Health and Welfare, 1398, Shimami‑cho, Kita‑ku, Niigata, 950‑3198, Japan.

Runa SorimachiDepartment of Physical Therapy, Niigata University of Health and Welfare, 1398, Shimami‑cho, Kita‑ku, Niigata, 950‑3198, Japan.

Rina NumataDepartment of Physical Therapy, Niigata University of Health and Welfare, 1398, Shimami‑cho, Kita‑ku, Niigata, 950‑3198, Japan.

Haruki HoshiDepartment of Physical Therapy, Niigata University of Health and Welfare, 1398, Shimami‑cho, Kita‑ku, Niigata, 950‑3198, Japan.

Naofumi OtsuruDepartment of Physical Therapy, Niigata University of Health and Welfare, 1398, Shimami‑cho, Kita‑ku, Niigata, 950‑3198, Japan.ORCID http://orcid.org/0000-0001-7163-1828

Sumiya ShibataDepartment of Physical Therapy, Niigata University of Health and Welfare, 1398, Shimami‑cho, Kita‑ku, Niigata, 950‑3198, Japan.ORCID http://orcid.org/0000-0001-6719-758X

Hideaki OnishiDepartment of Physical Therapy, Niigata University of Health and Welfare, 1398, Shimami‑cho, Kita‑ku, Niigata, 950‑3198, Japan.ORCID http://orcid.org/0000-0002-1060-8795

Funding

Japan Society for the Promotion of Science 24K14313

6 · The paper itself

Abstract

Non-invasive brain stimulation such as transcranial direct current stimulation over the primary motor cortex (M1) and supplementary motor area (SMA) during gait can positively affect gait ability in patients after stroke; however, the frequency-specific modulatory effects of rhythmic brain stimulation over the M1 and SMA on the oscillatory neural drives during gait remain unclear. Therefore, we investigated the effects of the alpha and beta to low-gamma oscillatory transcranial direct current stimulation (otDCS) over the M1 and SMA on the oscillatory neural drives to lower limb muscles during gait, using coherence analysis of paired surface electromyography, in 32 healthy young adults. Experiments involved treadmill gait measurements, comprising pre-stimulation gait, gait with otDCS in three stimulation conditions (10-Hz otDCS, 30-Hz otDCS, and sham stimulation) over the M1 and SMA, and post-stimulation gait. Although the 10-Hz otDCS and sham stimulation induced no effects, the 30-Hz otDCS over the M1 and SMA significantly increased the average values of the tibialis anterior intramuscular coherence and vastus medialis and lateralis intermuscular coherence, respectively, in the 20-40 Hz (beta to low-gamma) frequency bands during post-stimulation gait compared to the pre-stimulation gait. Therefore, beta to low-gamma otDCS over the M1 and SMA during gait selectively increased the oscillatory neural drives to distal and proximal lower limb muscles, respectively. This study provides novel evidence that beta to low-gamma rhythmic brain stimulation could be an effective rehabilitation strategy for improving gait ability in patients with central nervous system disorders, with specific deficits in the M1 or SMA.

Indexed as

Beta RhythmGaitGamma RhythmMotor CortexTranscranial Direct Current StimulationAdultElectromyographyEvoked Potentials, MotorFemaleHumansMaleMuscle, SkeletalYoung AdultBrain stimulationCoherenceCorticoreticular pathwayCorticospinal tractStrokeWalking

Identifiers

PMID41117923

DOI10.1007/s00221-025-07172-y

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.