Evidence map›Paper›PMID 41117921›Full record

ReviewGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026

Artificial intelligence in ophthalmology clinical trials: a narrative review.

Elham Rahmanipour, Samin Afazel, Sadra Ashrafi, Elham Sadeghi, Mohammad Ghorbani, Javier Zarranz-Ventura, Jay Chhablani

Abstract readReview
PubMed Publisher
In one paragraph

Review in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elham RahmanipourImmunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID 0000-0001-8454-458X
Samin AfazelSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID 0009-0004-3217-7211
Sadra AshrafiOphthalmology Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-2115-598X
Elham SadeghiSchool of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-3802-3219
Mohammad GhorbaniOrthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID 0000-0002-1097-4509
Javier Zarranz-VenturaHospital Clínic of Barcelona, University of Barcelona, Barcelona, Spain.ORCID 0000-0003-2338-8143
Jay ChhablaniSchool of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. jay.chhablani@gmail.com.ORCID 0000-0003-1772-3558

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artificial intelligence (AI) is progressively advancing across various medical specialties, particularly ophthalmology, to evaluate medical data, prevent diseases, and facilitate individualized treatment strategies. This narrative review investigates the current state of AI applications in ophthalmology clinical trials, focusing on patient monitoring, treatment optimization, and the diagnosis of prevalent ocular disorders. The implementation of AI techniques, such as deep learning and machine learning, improves the precision and efficacy of the process by evaluating ocular imaging data, such as OCTs, to diagnose various conditions, including diabetic retinopathy, age-related macular degeneration, glaucoma, and cataracts. Furthermore, AI has transformed patient recruiting, data management, and outcome assessment in clinical trials. In resource-limited settings, the combination of AI and teleophthalmology resulted in greater access to care. Despite its many positive aspects, we must address challenges like data bias, transparency, and ethical concerns to ensure the safe and equitable implementation of AI. As AI progresses, it has the capability to transform ophthalmic care and research, significantly improving patient outcomes and worldwide healthcare accessibility.

Indexed as

Artificial IntelligenceClinical Trials as TopicEye DiseasesOphthalmologyHumansArtificial intelligenceDeep learningDiagnosticsMachine learningOphthalmologyTeleophthalmology

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.