Evidence map›Paper›PMID 41117899›Full record

ArticleAnalytical and bioanalytical chemistry2025

Core-shell Au@4-MBA@Ag enhanced SERS immunochromatography for rapid and on-site detection of deoxynivalenol in animal feeds.

Xinyi Song, Zhaoyuan He, Siyuan Tan, Siyu Cong, Wuli Lu, Zedeng Mai, Mingsheng Jiang, Yu Wen, Cheng Liu, Hailan Chen

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Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Xinyi SongCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi University, Nanning, 530004, China.
Zhaoyuan HeCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi University, Nanning, 530004, China.
Siyuan TanCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi University, Nanning, 530004, China.
Siyu CongCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi University, Nanning, 530004, China.
Wuli LuCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi University, Nanning, 530004, China.
Zedeng MaiCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi University, Nanning, 530004, China.
Mingsheng JiangCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi University, Nanning, 530004, China.
Yu WenResearch Institute of Agriculture and Animal Husbandry Development, Guangxi University, Nanning, 530004, Guangxi, China.
Cheng LiuCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi University, Nanning, 530004, China. lcanderic@163.com.
Hailan ChenCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi University, Nanning, 530004, China. hlchen319@163.com.

Funding

College Students' Innovation and Entrepreneurship Training Program 202410593411Guangxi Key R&D Program Project AB241484035
6 · The paper itself

Abstract

Deoxynivalenol (DON), a highly stable and globally prevalent mycotoxin, has become a critical food safety concern due to its widespread contamination in animal feed, particularly in corn, wheat, and other cereal-based ingredients. As one of the most frequently detected mycotoxins in feedstuffs, DON contamination not only causes significant economic losses in livestock production but also poses severe health risks to animals, including vomiting, immunosuppression, and growth retardation, which may ultimately affect human health through the food chain. Existing detection methods for DON are often limited by time-consuming procedures or analytical complexity. Here, we report a novel surface-enhanced Raman scattering-based lateral flow immunoassay (SERS-LFIA) for rapid, sensitive, and specific detection of DON residues in animal feeds. The biosensor employs core-shell Au@4-MBA@Ag nanoparticles functionalized with 4-mercaptobenzoic acid (4-MBA) as a Raman reporter and DON-specific antibodies for target recognition. After systematic optimization, the SERS-LFIA platform achieved both qualitative and quantitative detection within 16 min, with an exceptionally low limit of detection (LOD) of 0.01 µg/kg. The assay demonstrated excellent specificity, showing no cross-reactivity with other major mycotoxins, including aflatoxin B

Indexed as

Animal FeedBenzoatesChromatography, AffinityFood ContaminationGoldMetal NanoparticlesSilverSpectrum Analysis, RamanSulfhydryl CompoundsTrichothecenesAnimalsBiosensing TechniquesImmunoassayLimit of DetectionMycotoxinsBenzoatesdeoxynivalenolGoldMycotoxinsSilverSulfhydryl CompoundsTrichothecenesCore-shell nanoparticlesDeoxynivalenolMycotoxin contaminationQuantitative detectionSERS immunochromatography

Identifiers

PMID41117899

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.