Trial reportEuropean journal of nutrition2025
Plasma carotenoids and skin carotenoid status response following short-term changes in carotenoid intakes: a randomised clinical trial.
Trial report in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04323826 (Effect of the Type and Emulsification of Dietary Fat on the Bioavailability of Fat-soluble Nutrients in Human), which is not on this map. Not yet cited in PubMed.
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The trial behind it
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Effect of the Type and Emulsification of Dietary Fat on the Bioavailability of Fat-soluble Nutrients in Human
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Authors and funding
4 authors.
Funding
Abstract
purposeThis study investigated the response kinetics of plasma carotenoids and skin carotenoid status (SCS) with short-term changes in carotenoid intakes in mostly healthy, young Asian adults.
methodsThis was a crossover, double-blinded randomised controlled trial with 4 acute interventions, whereby all participants (n = 16) consumed a 7-day low-carotenoid (LC) diet, followed by their habitual (HB) diet for about 15 days before the next LC diet. Fasting plasma carotenoids and SCS were assessed at baseline and post-intervention for all dietary periods using reversed-phase high-performance liquid chromatography and resonance Raman spectroscopy respectively. This study was registered in clinicaltrials.gov as NCT04323826.
resultsSignificantly greater individual and total plasma carotenoids (P < 0.001) were observed after the HB diets compared to LC diets overall. These were coupled with significant changes in total plasma carotenoids (P < 0.001) throughout the study and significant associations between changes in carotenoid intakes and changes in total plasma carotenoids (ρ = 0.731, P < 0.001). However, no significant differences in SCS (P = 0.83) were observed after the HB diets compared to LC diets overall, with no SCS changes observed throughout the study (P = 0.93). Moreover, no significant associations were observed between changes in carotenoid intakes and changes in SCS (ρ = -0.035, P = 0.71).
conclusionsPlasma carotenoids reflect short-term (7-day) changes in carotenoid intakes, while SCS does not. These results suggest that plasma carotenoids can serve as sensitive biomarkers for detecting short-term changes in carotenoid intakes while SCS may not be a suitable alternative biomarker for such applications.
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