ArticleMetabolic brain disease2025
Minocycline inhibits microglial activation and mitigates compulsive and anxiety-like behaviors induced by a high-refined carbohydrate diet in male BALB/c mice.
Article in Metabolic brain disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Consumption of a high-carbohydrate (HC) diet, which is commonly associated with obesity, has been linked to anxiety-like and compulsive behaviors. This association is predominantly attributed to chronic low-grade inflammation, which affects both the peripheral tissues and the central nervous system. Microglial cells, which are essential for neuroinflammation, exacerbate psychiatric disorders, such as depression and anxiety. Minocycline, a second-generation tetracycline antibiotic, exhibits anti-inflammatory and neuroprotective properties by modulating the activation of microglia. This study aimed to investigate whether minocycline alleviates compulsive and anxiety-like behaviors, as well as inflammatory responses, in mice fed an HC diet. Male BALB/c mice were fed standard chow (control diet) or high-carbohydrate (HC) diet for 12 weeks. Minocycline (50 mg/kg) was administered for 7 days (intraperitoneally) or 15 days (orally, by gavage) before the end of the dietary protocol. Behavioral assessments using the Marble Burying (MB) and novelty suppressed feeding (NSF) tests were conducted 24 h after the end of the diet. Brain, adipose tissue, and serum samples were analyzed for morphological and biochemical changes. Minocycline treatment for 15 days, but not for 7 days, reversed compulsive and anxiety-like behaviors. It also reduced microglial activation in the prefrontal cortex and the hippocampus. Despite these central effects, minocycline showed a limited influence on the peripheral metabolic parameters altered by the HC diet. This study highlights the role of microglial cells in HC diet-related behavioral changes in male mice and indicates that minocycline exerts central anti-inflammatory effects. These findings warrant further studies to confirm their relevance in other animal models and their potential applicability to anxiety and obsessive-compulsive disorders in humans.
Indexed as
Identifiers
41117867What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.