Evidence map›Paper›PMID 41117851›Full record

ReviewBiogerontology2025

Obstructive sleep apnea and aging of the cardiovascular system: a multidimensional analysis of the mechanisms involved.

Xiaolin Hao, Yan Li, Xiaoling Gao

Abstract readReview
PubMed Publisher
In one paragraph

Review in Biogerontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xiaolin HaoDepartment of the Second Clinical Medicine, Shanxi Medical University, Taiyuan, Shanxi, China.
Yan LiDepartment of the Second Clinical Medicine, Shanxi Medical University, Taiyuan, Shanxi, China.
Xiaoling GaoDepartment of Respiratory and Critical Care Medicine, The Second Hospital of Shanxi Medical University, No. 382 Wuyi Road, Xinghualing District, Taiyuan, Shanxi, 030001, People's Republic of China. yihexiyuan@sxmu.edu.cn.

Funding

National Natural Science Foundation of China Grant No. 82370091Research Project of the Health Commission of Shanxi Province Grant No. 2023XG027Technology Guidance Special Fund of the "Billion Project" in Higher Education of Shanxi Province Grant No. BYJL029Technology Innovation Plan for Medical Development of the Health Commission of Shanxi Province Grant No. 2023XM001Technology Transformation Guidance Special Fund of Shanxi Province Grant No. 202204021301068
6 · The paper itself

Abstract

Emerging evidence has revealed a strong association between obstructive sleep apnea (OSA) and aging. Considering the critical role of the cardiovascular system, this review explores the key mechanisms linking OSA to cardiovascular aging through a focus on chronic intermittent hypoxia (CIH) -induced oxidative stress and chronic inflammation. Specifically, we examine six key pathways: (1) cellular senescence, (2) mitochondrial dysfunction, (3) metabolic dysregulation, (4) telomere attrition, (5) impaired intercellular communication, and (6) adipose tissue senescence. These insights provide a foundation for identifying novel interventions and therapeutic targets to mitigate or even reverse cardiovascular aging.

Indexed as

AgingCardiovascular DiseasesCardiovascular SystemSleep Apnea, ObstructiveAnimalsCellular SenescenceHumansInflammationOxidative StressAdipose tissue senescenceCardiovascular system agingMetabolic dysregulationMitochondrial dysfunctionObstructive sleep apnea

Identifiers

PMID41117851

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.