Evidence map›Paper›PMID 41117846›Full record

SynthesisChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2025

Stereotactic radiosurgery in the treatment of pediatric cerebral cavernous malformations: a systematic review and meta-analysis of outcomes and safety.

Bibhas Amatya, Ritvik Pulya, Julian Gendreau, Mickey E Abraham

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bibhas Amatya *Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Ritvik Pulya *Department of Biomedical Engineering, Johns Hopkins Whiting School of Engineering, Baltimore, MD, USA.
Julian GendreauDepartment of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Mickey E AbrahamDepartment of Neurological Surgery, University of California San Diego Health, San Diego, CA, USA. mabraham@health.ucsd.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral cavernous malformations (CCMs) are clusters of dilated, thin-walled vascular channels that pose significant neurological risks, particularly in pediatric patients. While stereotactic radiosurgery (SRS) has been explored as a non-invasive treatment modality, its safety and efficacy in children remain incompletely defined. We conducted a systematic review and meta-analysis of single-arm proportions after SRS for pediatric CCMs. PubMed and the Cochrane Library were searched; four retrospective cohort studies met inclusion criteria. Random-effects pooled proportions were calculated for key outcomes. Post-SRS seizure proportion (three studies; n = 73) was 0.23 (95% CI, 0.11-0.37; I

Indexed as

Hemangioma, Cavernous, Central Nervous SystemRadiosurgeryChildHumansTreatment OutcomeCavernous malformationsPediatricsRadiosurgery

Identifiers

PMID41117846

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.