Evidence map›Paper›PMID 41117845›Full record

ArticleNeuro-oncology2026

Integrated clinical and molecular landscape of disseminated pediatric low-grade glioma.

Adrian B Levine, Julie Bennett, Prabhumallikarjun Patil, Ian Burns, Robert Siddaway, Cyril Li, Joseline Haizel-Cobbina, Mansuba Rana, Richard Yuditskiy, Andrew Son and 63 more

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Article in Neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

73 authors.

Adrian B LevineArthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0003-1048-3360
Julie BennettArthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0002-4146-1511
Prabhumallikarjun PatilDepartment of Hematology-Oncology, Aflac Cancer Center, Childrens Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA.
Ian BurnsDepartment of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada.
Robert SiddawayArthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, ON, Canada.
Cyril LiArthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, ON, Canada.
Joseline Haizel-CobbinaDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Mansuba RanaArthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, ON, Canada.
Richard YuditskiyArthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, ON, Canada.
Andrew SonArthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, ON, Canada.
Yoshiko NakanoNeuro-Oncology Section, Division of Haematology Oncology, Hospital for Sick Children, Toronto, ON, Canada.
Palak PatelArthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, ON, Canada.
I-Chen HoArthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, ON, Canada.
Michelle KuArthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, ON, Canada.
Alexander T LyonsVanderbilt University School of Medicine, Nashville, TN, USA.
José E Velázquez VegaDepartment of Pathology and Laboratory Medicine, Children's Healthcare of Atlanta, Atlanta, GA, USA.
Matthew J SchniederjanDepartment of Pathology and Laboratory Medicine, Children's Healthcare of Atlanta, Atlanta, GA, USA.
Craig ErkerHematology/Oncology, IWK Health Centre, Dalhousie University, Halifax, NS, Canada.ORCID 0000-0003-1394-7167
Chantel CacciottiPediatric Hematology/Oncology, Children's Hospital London Health Sciences, Western University, London, ON, Canada.
Mariarita SantiDepartment of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Ernest J NelsonDepartment of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Sylvia ChengDepartment of Pediatrics, Division of Pediatric Hematology/Oncology/BMT, B.C. Children's Hospital, Vancouver, BC, Canada.
Christopher DunhamPathology and Laboratory Medicine, BC Children's Hospital, Vancouver, BC, Canada.ORCID 0000-0002-6244-0584
Bev WilsonPediatric Oncology, Stollery Children's Hospital, University of Alberta, Edmonton, AB, Canada.
Karina BlackPediatric Oncology, Stollery Children's Hospital, University of Alberta, Edmonton, AB, Canada.
Frank Van LandeghemDepartment of Laboratory Medicine & Pathology, Walter Mackenzie Health Sciences Centre, University of Alberta, Edmonton, AB, Canada.
Liana NobreNeuro-Oncology Section, Division of Haematology Oncology, Hospital for Sick Children, Toronto, ON, Canada.
David D EisenstatDepartments of Oncology, Pediatrics and Medical Genetics, University of Alberta, Edmonton, AB, Canada.
Ana S Guerreiro StücklinDivision of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Annette WeiserDivision of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Valerie LaroucheDepartment of Pediatrics, Division of Hemato-Oncology, CHU de Québec-Université Laval, Quebec, QC, Canada.
Panagiota GiannakourosDepartment of Pediatrics, Division of Hemato-Oncology, CHU de Québec-Université Laval, Quebec, QC, Canada.
Adriana FonsecaPediatric Oncology, Children's National Hospital, Washington, DC, USA.
Lane WilliamsonPediatric Oncology, Children's National Hospital, Washington, DC, USA.
Igor L FernandesBacchi Laboratory, São Paulo, Brazil.
Ashley S Plant-FoxDivision of Hematology, Stem Cell Transplant, and Neuro-Oncology, Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Adam FlemingPediatric Hematology/Oncology, McMaster Children's Hospital, Hamilton Health Sciences, Hamilton, ON, Canada.
Shawde CampbellPediatric Hematology/Oncology, McMaster Children's Hospital, Hamilton Health Sciences, Hamilton, ON, Canada.
Naureen MushtaqDepartment of Oncology, Section of Pediatric Oncology, Aga Khan University Hospital, Karachi, Pakistan.ORCID 0000-0002-5461-3350
Syed Ibrahim BukhariDepartment of Oncology, Section of Pediatric Oncology, Aga Khan University Hospital, Karachi, Pakistan.
Khurram MinhasPathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, Pakistan.
Richard T GrahamDivision of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Scott RaskinDivision of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Filip Jadrijevic-CvrljePediatric Hematology/Oncology, Children's Hospital Zagreb, Zagreb, Croatia.
Louise LudlowChildren's Cancer Centre, Royal Children's Hospital; Children's Cancer Centre Biobank, Murdoch Children's Research Institute, Melbourne, VIC, Australia.
Mary V MacneilMedical Oncology, Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada.
Jean M Mulcahy-LevyMorgan Adams Foundation Pediatric Brain Tumor Research Program, Children's Hospital Colorado, Aurora, CO, USA.
Samantha DemarshMorgan Adams Foundation Pediatric Brain Tumor Research Program, Children's Hospital Colorado, Aurora, CO, USA.
Kohei FukuokaDepartment of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.
Kai YamasakiJapanese Children's Cancer Group (JCCG) (K.F., K.Y., T.S., F.O., A.K., Y.A., T.I., F.Y.).
Tomonari SuzukiJapanese Children's Cancer Group (JCCG) (K.F., K.Y., T.S., F.O., A.K., Y.A., T.I., F.Y.).
Fumiharu OhkaJapanese Children's Cancer Group (JCCG) (K.F., K.Y., T.S., F.O., A.K., Y.A., T.I., F.Y.).
Atsufumi KawamuraJapanese Children's Cancer Group (JCCG) (K.F., K.Y., T.S., F.O., A.K., Y.A., T.I., F.Y.).
Yoshiki ArakawaJapanese Children's Cancer Group (JCCG) (K.F., K.Y., T.S., F.O., A.K., Y.A., T.I., F.Y.).ORCID 0000-0003-4626-4645
Takashi IshiharaJapanese Children's Cancer Group (JCCG) (K.F., K.Y., T.S., F.O., A.K., Y.A., T.I., F.Y.).
Fumiyuki YamasakiJapanese Children's Cancer Group (JCCG) (K.F., K.Y., T.S., F.O., A.K., Y.A., T.I., F.Y.).ORCID 0000-0003-0164-6295
Jordan R HansfordMichael Rice Centre for Hematology and Oncology, Women's and Children's Hospital, North Adelaide, SA, Australia.
Amanda LuckMichael Rice Centre for Hematology and Oncology, Women's and Children's Hospital, North Adelaide, SA, Australia.
Maclean P NasrallahPathology and Laboratory Medicine, University of Pennsylvania, Pennsylvania, PA, USA.
Helen ToledanoPediatric Hematology-Oncology, Schneider Children's Medical Center, Petach Tikva and Tel Aviv University, Israel.
Roaya M MasoudPediatric Hematology-Oncology, Schneider Children's Medical Center, Petach Tikva and Tel Aviv University, Israel.
Alvaro LassalettaPediatric Neuro-Oncology, Hospital Universitario Niño Jesús, Madrid, Spain.
Luis Blasco-SantanaPathology Department, Hospital Infantil Universitario Niño Jesus, Madrid, Spain.
John-Paul KildayThe Geoffrey Jefferson Brain Research Centre, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.ORCID 0000-0002-0539-215X
Alisa TalianskiNeuro-Oncology Unit, The Chaim Sheba Medical Center, Tel Ha Shomer, Ramat Gan, Israel.
Caroline DaviesDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.
James JohnstonDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Andrew T HaleDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Peter B DirksArthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, ON, Canada.
James T RutkaArthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, ON, Canada.
Michael C DewanDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Uri TaboriArthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0002-5019-2683
Cynthia E HawkinsArthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0003-2618-4402

Funding

Brain Tumor Foundation of CanadaCIHR 399868CIHR 480606Hospital for Sick Children # 1156-03Pediatric Brain Tumor FoundationRally for the Cure FoundationSickKids Clinician Scientist Training ProgramSickKids FoundationTerry Fox Research Institute Program Projects Grant
6 · The paper itself

Abstract

abstractBackgroundPediatric-type low-grade gliomas (PLGG) are the most common central nervous system (CNS) tumor in children. Many are indolent and have excellent outcomes; however, some inexplicably spread throughout the CNS leading to increased morbidity and mortality.

methodsTo better understand this rare and difficult-to-treat entity, as well as the features associated with dissemination in CNS tumors, we assembled a large international cohort (n = 269) of patients with disseminated PLGG with detailed clinical and molecular characterization, including DNA sequencing and methylome profiling.

resultsWe identified three subgroups of patients based on the temporal and spatial distribution of dissemination. Tumors with diffuse leptomeningeal spread without a primary tumor mass and those occurring in infants had the worst clinical outcomes. The genetics overlapped substantially with that of non-disseminated PLGG, suggesting that non-genetic mechanisms are an important contributor to dissemination. Therapeutically, targeted RAS/MAPK-pathway inhibition was more effective than conventional chemotherapy as first or second-line treatment.

conclusionsIn sum, this cohort increases our clinical and biological understanding of this rare disease, provides insights for improving patient care, and directs future clinical trials and basic science research.

Indexed as

Biomarkers, TumorBrain NeoplasmsGliomaAdolescentChildChild, PreschoolCohort StudiesDNA MethylationFemaleFollow-Up StudiesHumansInfantMaleNeoplasm GradingPrognosisSurvival RateBiomarkers, Tumorcancer metastasisCNS tumoursliquid biopsylow-grade gliomamethylationnext generation sequencingpediatric cancerpediatric neuro-oncologytargeted therapy

Identifiers

PMID41117845
PMCPMC12979044

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.