Evidence map›Paper›PMID 41117797›Full record

Trial reportJNCI cancer spectrum2025

Effects of aerobic exercise on late effects and quality of life in long-term breast cancer survivors: a randomized controlled trial.

Sara Hassing Johansen, Kristin V Reinertsen, Torbjørn Wisløff, Mali Sæter, Sebastian Imre Sarvari, Cecilie E Kiserud, Nora Strandos, Elisabeth Edvardsen, May Grydeland, Tormod S Nilsen and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in JNCI cancer spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04307407 (The Cause Trial), which is not on this map. Cited by 2 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04307407 nacompletednot on this map

The Cause Trial: A Randomized Trial of Aerobic Exercise on CVD Risk Factors in Breast Cancer Survivors

TypeinterventionalSponsorNorwegian School of Sport SciencesRan2020 to 2023Enrolled210ConditionsBreast CancerArmsAerobic Exercise
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sara Hassing JohansenDepartment of Physical Performance, The Norwegian School of Sport Sciences, Oslo, Norway.ORCID 0000-0002-1788-1057
Kristin V ReinertsenDepartment of Oncology, Division of Cancer Medicine, Oslo, Norway.ORCID 0000-0003-0433-8589
Torbjørn WisløffInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0002-7539-082X
Mali SæterInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Sebastian Imre SarvariProCardio Center for Innovation, Department of Cardiology, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-0808-8866
Cecilie E KiserudDepartment of Oncology, Division of Cancer Medicine, Oslo, Norway.
Nora StrandosDepartment of Physical Performance, The Norwegian School of Sport Sciences, Oslo, Norway.
Elisabeth EdvardsenDepartment of Physical Performance, The Norwegian School of Sport Sciences, Oslo, Norway.ORCID 0000-0002-9414-6638
May GrydelandDepartment of Physical Performance, The Norwegian School of Sport Sciences, Oslo, Norway.ORCID 0000-0001-6945-7170
Tormod S NilsenDepartment of Physical Performance, The Norwegian School of Sport Sciences, Oslo, Norway.ORCID 0000-0002-9380-2808
Lene ThorsenDepartment of Oncology, Division of Cancer Medicine, Oslo, Norway.

Funding

Norwegian Cancer Society and Aktiv mot KreftNorwegian Research Council #309762ProCardio Center for Research-based Innovation
6 · The paper itself

Abstract

backgroundBreast cancer survivors (BCSs) are at increased risk of late effects. While research has reported positive effects of exercise therapy on fatigue and health-related quality of life (HRQoL) among short-term BCSs, evidence in long-term survivors remains scarce.

methodsThe CAUSE (CArdiovascUlar Survivors Exercise) trial was a 2-armed randomized controlled trial. Long-term BCSs were assigned to 5 months of thrice-weekly supervised aerobic exercise or usual care. Late effects and HRQoL were assessed by Chalder Fatigue Questionnaire, European Organization for Research and Treatment of Cancer QLQ-BR23 and QLQ-C30 questionnaires, and Scale for Chemotherapy-Induced Long-term Neurotoxicity at baseline (T0), post-intervention (T1), and 1-year follow-up (T2).

resultsIn total, 140 BCSs (mean age 59.0 ± 6.4 years, 11 ± 1 years post-treatment) were included. Loss to follow-up at T1 was 6% and 19% in the exercise- and usual care group, respectively. From T0 to T1, the exercise group significantly improved total fatigue (between groups mean difference [MD] = -3.0, P < .001), body image (MD = 6.7, P = .043), physical- (MD = 3.2, P ≤ .001), role- (MD = 9.6, P = .019), and cognitive function (MD = 3.4, P = .038), insomnia (MD = -9.0, P = .017), and global health/QoL (MD = 5.3, P ≤ .001) compared to usual care. The exercise benefits were more pronounced in BCSs experiencing versus not experiencing late effects at baseline. At 1-year follow-up, most improvements regressed toward baseline values.

conclusionAerobic exercise significantly improves fatigue, body image, physical-, role-, and cognitive function, insomnia, and HRQoL in long-term BCSs. These findings suggest that exercise therapy should be a core component of managing late effects and enhancing HRQoL in long-term BCSs. CLINICAL

trial registrationURL: https://www.clinicaltrials.gov/. Registration number: NCT04307407.

Indexed as

Breast NeoplasmsCancer SurvivorsExerciseExercise TherapyQuality of LifeAgedFatigueFemaleHumansMiddle AgedSurveys and Questionnaires

Identifiers

PMID41117797
PMCPMC12613246

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.