Evidence map›Paper›PMID 41117669›Full record

SynthesisAddiction (Abingdon, England)2026

Systematic review of patient-reported outcome measures for opioid use disorder recovery.

Jarratt D Pytell, Dennis Pales, Caty Simon, Jarett Beaudoin, Ahmed M Y Osman, Ellie Svoboda, Paul J Christine, Daniel Matlock, Robert Schwartz, Ingrid A Binswanger

Abstract readSystematic Review
In one paragraph

Synthesis in Addiction (Abingdon, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jarratt D PytellDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0002-5394-609X
Dennis PalesDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Caty SimonNC Survivors Union, Greensboro, NC, USA.
Jarett BeaudoinDepartment of Family and Community Medicine, University of California Davis School of Medicine, Sacramento, CA, USA.
Ahmed M Y OsmanDepartment of Pharmacy Practice, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan, Malaysia.
Ellie SvobodaStrauss Health Sciences Library, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Paul J ChristineDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0003-1707-0761
Daniel MatlockDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Robert SchwartzFriends Research Institute, Baltimore, MD, USA.
Ingrid A BinswangerDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0001-8862-8078

Funding

Patient Reported Outcome Measures to Individualize Treatment And Improve ReteNtion (ReTAIN) program in primary care-based OUD treatmentK23DA060358 · NIDA · UNIVERSITY OF COLORADO DENVER · PI Jarratt Pytell · 2024 to 2026
$570k
NIDA NIH HHS K23 DA060358NIH HHS K23DA060358
6 · The paper itself

Abstract

BACKGROUND AND

aimsRecovery-focused measurement-based care of opioid use disorder (OUD) could inform clinical care by assessing patient-reported outcome measures (PROMs). We sought to identify and describe validated PROMs which assess recovery among patients with OUD, focusing on PROM characteristics, recovery domains and pragmatism for implementation in outpatient settings.

methodsA preregistered (PROSPERO: CRD42023394770) systematic review was conducted using the Consensus-based Standards for the selection of health Measurement Instruments (COSMIN) guidelines. Validated PROMs that assessed at least one of 17 recovery domains and contained fewer than 50 items were identified. The review described PROM characteristics, including the number of items, subscales, response options and time to complete. Content validity was assessed from the patient perspective. Recovery domains assessed were categorized into 17 domains, including substance-related, psychological health and quality of life. The presence of clinically relevant score changes was assessed. Hierarchical clustering was performed to describe co-occurrence patterns among recovery domains.

resultsA total of 122 studies were included, identifying 90 unique PROMs. Three PROMs (3%) received a 'moderate' grade on content validity. PROMs assessed a median of 4 recovery domains [inter-quartile range (IQR) = 1-7], with substance-related outcomes being most common (51%), followed by psychological health (49%), relationships (41%) and physical health (36%). Nineteen PROMs (21%) contained fewer than 10 items, making them highly pragmatic for clinical use. Fourteen PROMs (16%) assessed 8 or more recovery domains and were categorized as comprehensive. Two (2%) comprehensive PROMs were developed with input from individuals with lived experience of substance use, providing a patient-centered perspective. Five PROMs (6%) defined clinically relevant score changes.

conclusionsThere are many patient-reported outcome measures (PROMs) which assess diverse and often broadly defined recovery domains that can be used in recovery-focused measurement-based care of opioid use disorder; however, few PROMs are brief enough to be pragmatic for clinical use, nearly all lack clinically relevant score changes that could help inform treatment decisions, and few were developed with input from people with lived experience.

Indexed as

Opioid-Related DisordersPatient Reported Outcome MeasuresHumansQuality of Lifemeasurement‐based careopioid use disorderpatient‐reported outcomeprimary carerecoverysystematic review

Identifiers

PMID41117669
PMCPMC12679855

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.