Evidence map›Paper›PMID 41117607›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2025

Investigating the impact of age on neurodegeneration after optic neuritis in multiple sclerosis using optical coherence tomography.

Henriette Km Reinsberg, Frederike C Oertel, Daniel Casillas, Gelsomina Kaufhold, Shivany Condor Montes, Charlotte Bereuter, Makenna C Chapman, Pia S Sperber, Bruce A Cree, Judith Bellmann-Strobl and 8 more

Abstract read
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In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Henriette Km ReinsbergWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco (UCSF), San Francisco, CA, USA.ORCID 0009-0008-3215-2910
Frederike C OertelWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco (UCSF), San Francisco, CA, USA.ORCID 0000-0003-4906-5983
Daniel CasillasWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco (UCSF), San Francisco, CA, USA.
Gelsomina KaufholdExperimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Shivany Condor MontesWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco (UCSF), San Francisco, CA, USA.ORCID 0000-0003-1211-6046
Charlotte BereuterExperimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Makenna C ChapmanWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco (UCSF), San Francisco, CA, USA.
Pia S SperberExperimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Bruce A CreeWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco (UCSF), San Francisco, CA, USA.ORCID 0000-0001-7689-2533
Judith Bellmann-StroblExperimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Stephen L HauserWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco (UCSF), San Francisco, CA, USA.ORCID 0000-0002-4932-4001
Tanja Schmitz-HübschExperimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Christian CordanoWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco (UCSF), San Francisco, CA, USA.ORCID 0000-0002-1413-0442
Hanna G ZimmermannExperimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Ahmed AbdelhakWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco (UCSF), San Francisco, CA, USA.ORCID 0000-0001-9731-4169
Friedemann PaulExperimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Ari J GreenWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco (UCSF), San Francisco, CA, USA.ORCID 0000-0001-9275-3066
University of California, San Francisco MS-EPIC Team

Funding

The Four Repeat Tauopathy Neuroimaging InitiativeR01AG038791 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2010 to 2020
$18.1M
The Role of B cells in the Origin and Progression of Multiple SclerosisR35NS111644 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEPHEN L HAUSER · 2019 to 2026
$9.1M
Tracking longitudinal change in presymptomatic genetic prion disease (TLC-Pre-gPrD)R01AG062562 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GESCHWIND, MICHAEL D · 2019 to 2023
$5.4M
Establishing VEP as a quantitative biomarker for remyelination using transgenic models for gain and loss of functionR01NS105741 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GREEN, ARI J · 2018 to 2022
$1.8M
NIA NIH HHS R01 AG038791NIA NIH HHS R01 AG062562NINDS NIH HHS R01 NS105741NINDS NIH HHS R35 NS111644
6 · The paper itself

Abstract

backgroundWhile disability progression in multiple sclerosis (MS) is age-dependent, the exact timing of neuroaxonal degeneration throughout the patient lifespan remains unclear.

objectivesTo investigate the influence of age on retinal neurodegeneration after the first unilateral episode of optic neuritis (ON).

methodsWe measured peripapillary retinal nerve fibre layer (pRNFL) and macular ganglion cell inner plexiform layer (mGCIPL) absolute thickness and intereye differences (IEDs) in 61 MS patients with a single unilateral ON 6-24 months prior (MS-ON) and 61 MS patients without ON history (MS-NON). Participants were 1:1 matched based on age, sex, and Expanded Disability Status Scale (EDSS). Statistical significance was evaluated using mixed linear effects models.

resultsAge and ON status of eyes significantly interacted in predicting absolute pRNFL and mGCIPL thickness (pRNFL: DISCUSSION: Our data show evidence of increased relapse-associated neuroaxonal damage in older individuals. This suggests less neuronal resilience following attacks and implicates age-effects beyond insidious progression. The growing population of older people with MS (pwMS) may be at increased risk of neurodegeneration and permanent disability worsening after acute MS attacks. Longitudinal studies should confirm this.

Indexed as

AgingMultiple SclerosisNerve DegenerationOptic NeuritisRetinaRetinal Ganglion CellsAdultAge FactorsDisease ProgressionFemaleHumansMaleMiddle AgedTomography, Optical CoherenceAgingaxonal lossdisabilitymultiple sclerosisneurodegenerationoptic neuritis

Identifiers

PMID41117607
PMCPMC12547046

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.