Evidence map›Paper›PMID 41117552›Full record

ReviewPlant biotechnology journal2026

Synthetic Biology and Metabolic Engineering of Microalgae for Sustainable Lipid and Terpenoid Production: An Updated Perspective.

Ty Shitanaka, Yu Wang, Sally Do, Julia Yuson, Samir Kumar Khanal, Krzysztof Zienkiewicz, Zhi-Yan Du

Abstract readReview
In one paragraph

Review in Plant biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Screening of the TwoMicroorganisms · 2026
    Article
  6. Article
  7. Review
  8. Harnessing microalgae for bioproducts: innovations in synthetic biology.World journal of microbiology & biotechnology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ty ShitanakaDepartment of Molecular Biosciences & Bioengineering, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
Yu WangDepartment of Molecular Biosciences & Bioengineering, University of Hawaii at Manoa, Honolulu, Hawaii, USA.ORCID https://orcid.org/0009-0005-0661-311X
Sally DoDepartment of Molecular Biosciences & Bioengineering, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
Julia YusonDepartment of Molecular Biosciences & Bioengineering, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
Samir Kumar KhanalDepartment of Molecular Biosciences & Bioengineering, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
Krzysztof ZienkiewiczCentre for Modern Interdisciplinary Technologies, Nicolaus Copernicus University in Toruń, Toruń, Poland.ORCID https://orcid.org/0000-0002-8525-9569
Zhi-Yan DuDepartment of Molecular Biosciences & Bioengineering, University of Hawaii at Manoa, Honolulu, Hawaii, USA.ORCID https://orcid.org/0000-0001-7646-2429

Funding

College of Tropical Agriculture and Human Resilience, University of Hawaii at Manoa CARESCenters5047HNarodowe Centrum Nauki 2019/35/B/NZ9/01075National Science Foundation 2121410U.S. Department of Agriculture CTSA-2022-38500-38099U.S. Department of Agriculture HAW05057-H
6 · The paper itself

Abstract

Microalgae are increasingly recognised as powerful platforms for the sustainable production of lipids and terpenoids, with expanding applications in the food, fuel and biomanufacturing industries. In this updated review, we consolidate and critically assess the most recent advances in synthetic biology and metabolic engineering of key microalgal models, including Chlamydomonas reinhardtii, Nannochloropsis spp. and Phaeodactylum tricornutum. We focus on developments that have emerged in the latest waves of research, emphasising novel genetic toolkits that accelerate the Design-Build-Test-Learn (DBTL) cycle, breakthroughs in genome-scale metabolic modelling, and innovative strategies for organelle-targeted biosynthesis of high-value compounds. Recent case studies are compared to highlight trends in successful engineering approaches. By capturing these up-to-date insights, this review outlines the current trajectory of microalgal biotechnology toward scalable, carbon-neutral biofactories for polyunsaturated fatty acids (PUFAs) and diverse terpenoids, reinforcing their role in global sustainability and the circular bioeconomy.

Indexed as

LipidsMetabolic EngineeringMicroalgaeSynthetic BiologyTerpenesBiotechnologyLipidsTerpenescarotenoidsmetabolic engineeringmicroalgaepolyunsaturated fatty acids(PUFAs) sterolsterpenes

Identifiers

PMID41117552
PMCPMC12946468

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.