Evidence map›Paper›PMID 41117488›Full record

ArticleHistology and histopathology2026

C6orf15 expression in thyroid tumors: A promising diagnostic biomarker for the classic variant of papillary thyroid carcinoma.

Aobo Xu, Pengju Zhang, Jiaxin Chai, Jiandong Wang, Pengfei Huang, Xudong Gu

Abstract read
PubMed Publisher
In one paragraph

Article in Histology and histopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aobo Xu *Research Institute of General Surgery, Jinling Hospital, Nanjing Medical University, Nanjing, China.
Pengju Zhang *Research Institute of General Surgery, Jinling Hospital, Nanjing Medical University, Nanjing, China.
Jiaxin ChaiDepartment of Pathology, Nanjing JunXie Hospital, Nanjing, Jiangsu Province, China.
Jiandong WangDepartment of Pathology, Jinling Hospital, Nanjing Medical University, Nanjing, China. jiandong_wang@nju.edu.cn.
Pengfei HuangDepartment of Ultrasound, Jinling Hospital, Nanjing Medical University, Nanjing, China. fei.0727@163.com.
Xudong GuDay Surgery Management Center, Jinling Hospital, Nanjing Medical University, Nanjing, China.

Funding

Jinling Hospital Research Project 2024JCYZD071
6 · The paper itself

Abstract

Although C6orf15 is highly expressed in certain human cancers, its expression pattern in papillary tumors remains unclear. In this study, we investigated C6orf15 expression in papillary tumors and assessed its potential as a diagnostic biomarker for histopathological evaluation and fine-needle aspiration cytology (FNAC). We collected a total of 87 formalin-fixed and paraffin-embedded (FFPE) thyroid tissue specimens that included: 10 cases with Hashimoto's thyroiditis (HT), 11 with follicular adenomas (FAs), two with non-invasive follicular thyroid neoplasms with papillary-like nuclear feature (NIFTP), six with follicular thyroid carcinomas (FTCs), three with invasive encapsulated follicular variant of papillary thyroid carcinomas (IEFVPTCs), three with medullary thyroid carcinomas (MTCs), and 52 with papillary thyroid carcinomas (PTCs). Additionally, 33 FNAC samples from thyroid nodules were analyzed, comprising three samples of FA, five atypia of undetermined significance (AUS), and 25 cases of PTC. Immunohistochemical (IHC) staining was performed to assess C6orf15 expression in thyroid tumor tissues and FNAC samples. We conducted

Indexed as

Biomarkers, TumorThyroid Cancer, PapillaryThyroid NeoplasmsAdultAgedBiopsy, Fine-NeedleFemaleHumansImmunohistochemistryMaleMiddle AgedMutationProto-Oncogene Proteins B-rafBiomarkers, TumorBRAF protein, humanProto-Oncogene Proteins B-raf

Identifiers

PMID41117488

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.