Evidence map›Paper›PMID 41117373›Full record

ArticleMolecular pharmaceutics2025

Positron Emission Tomography/Computed Tomography (PET/CT) and Radioimmunotherapy of Head and Neck Cancer Patient Derived Xenografts in NRG Mice with Theranostic [

Meysam Khosravifarsani, Conrad Chan, Anthony Ku, Noor Alsaden, Jalna Meens, Laurie Ailles, Scott Bratman, Raymond M Reilly

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Meysam KhosravifarsaniDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College St., Toronto, Ontario M5S 3M2, Canada.
Conrad ChanDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College St., Toronto, Ontario M5S 3M2, Canada.ORCID 0009-0001-3099-1082
Anthony KuDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College St., Toronto, Ontario M5S 3M2, Canada.
Noor AlsadenDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College St., Toronto, Ontario M5S 3M2, Canada.
Jalna MeensPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada.ORCID 0000-0001-5274-3744
Laurie AillesPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada.ORCID 0000-0001-7289-8882
Scott BratmanPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada.ORCID 0000-0001-8610-4908
Raymond M ReillyDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College St., Toronto, Ontario M5S 3M2, Canada.ORCID 0000-0003-1038-7993

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck squamous cell carcinoma (HNSCC) expresses epidermal growth factor receptors (EGFR) in 90% of cases. Here we studied PET/CT imaging of three clinically relevant HNSCC patient derived xenografts (PDX) with low (#61531), moderate (#73191) or high (#88955) EGFR expression in NRG mice using anti-EGFR [

Indexed as

Head and Neck NeoplasmsPanitumumabPositron Emission Tomography Computed TomographyRadioimmunotherapySquamous Cell Carcinoma of Head and NeckAnimalsCell Line, TumorCopper RadioisotopesErbB ReceptorsFemaleHumansImmunoconjugatesLutetiumMiceRadioisotopesRadiopharmaceuticalsCopper-64Copper RadioisotopesEGFR protein, humanErbB ReceptorsImmunoconjugatesLutetiumLutetium-177PanitumumabRadioisotopesRadiopharmaceuticalscopper-64head and neck cancerlutetium-177panitumumabpatient-derived xenografts (PDX)PET/CTradioimmunotherapytheranostics

Identifiers

PMID41117373
PMCPMC12588292

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.