Evidence map›Paper›PMID 41117265›Full record

ArticleAging cell2025

The Metabolic Transition Between Fasting and Feeding Alters Aging-Associated Metabolites, Lowers BCAAs, and Stimulates FGF21 Production in Humans.

Maria Lastra Cagigas, Nancy T Santiappillai, Serena Commissati, Giovanni Fiorito, Andrius Masedunskas, Gayathiri Rajakumar, Isabella de Ciutiis, Alan Goldhamer, Brian K Kennedy, Andrew J Hoy and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. ACS central science · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maria Lastra CagigasCharles Perkins Centre, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia.ORCID 0000-0001-5464-2349
Nancy T SantiappillaiSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia.
Serena CommissatiDepartment of Geriatrics, Ca' Foncello Treviso Hospital, Treviso, Italy.
Giovanni FioritoClinical Bioinformatics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Andrius MasedunskasCharles Perkins Centre, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia.
Gayathiri RajakumarSydney Medical School Nepean, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia.
Isabella de CiutiisCharles Perkins Centre, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia.
Alan GoldhamerTrueNorth Health Center, Santa Rosa, California, USA.
Brian K KennedyHealthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Andrew J HoySchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia.
Luigi FontanaCharles Perkins Centre, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia.ORCID 0000-0001-8500-5537

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
National Health and Medical Research Council APP1177797NCI NIH HHS P30 CA008748Schmidt Futures, Schmidt Science FellowshipUniversity of Sydney, Robison Fellowship
6 · The paper itself

Abstract

Fasting-based interventions are gaining momentum as strategies to modulate longevity. Conversely, the same metabolic adaptations that once ensured survival during starvation now contribute to the global obesity epidemic. While previous studies have characterized metabolic changes during fasting, few have examined the refeeding phase, and most lack an integrated analysis of key hormonal and metabolic regulators, including insulin, leptin, adiponectin, free T3, FGF21, and the plasma metabolome. To address this gap, we profiled 134 plasma metabolites using mass spectrometry, covering pathways involved in lipid, amino acid, and ketone metabolism, in a cohort of 20 adults (mean age 52.2 ± 11.8 years, 55% women, BMI 28.8 ± 6.4 kg/m

Indexed as

AgingAmino Acids, Branched-ChainFastingFibroblast Growth FactorsAdultAgedFemaleHumansMaleMetabolomeMiddle AgedAmino Acids, Branched-ChainFGF21 protein, humanfibroblast growth factor 21Fibroblast Growth FactorsBCAAfastingFGF21ketogenesisrefeeding

Identifiers

PMID41117265
PMCPMC12686557

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.