Observational studyActas espanolas de psiquiatria2025
Exploring the Link Between Enriched Environment and Depression: Insights From Human Participants.
Observational study in Actas espanolas de psiquiatria, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMajor depressive disorder (MDD) is a prevalent neuropsychiatric condition associated with significant functional impairment and reduced quality of life. Environmental enrichment (EE), a model encompassing cognitive, social, and physical activities, has demonstrated antidepressant effects in animal models through mechanisms involving brain plasticity. In humans, the influence of EE on depressive symptoms and its clinical significance remain under investigation. This study evaluated the relationship between EE domains and the clinical symptoms of MDD, focusing on the possible modulatory effects of EE on depressive symptomatology.
methodsWe conducted an observational, cross-sectional study involving 50 adults diagnosed with MDD. Depressive symptoms were assessed using the 17-items Hamilton Depression Rating Scale (17-HDRS), and EE levels were measured using the Environmental Enrichment Indicator (EEI), which evaluates cognitive, social, and physical activity domains. Correlations between depressive symptoms and EEI domains were analyzed.
resultsParticipants with higher 17-HDRS scores generally exhibited lower levels of EE. Additionally, individuals with more severe depressive symptoms were less likely to engage in cognitive activities compared to those with milder symptoms; however, this difference was not statistically significant (Kruskal-Wallis test, H = 3.82, df = 2, p = 0.14). Notably, higher EE levels were observed among younger participants.
conclusionsThe level of EE in individuals with depression may affect symptom severity. Further studies in clinical populations are needed to clarify the relationship between EE and depressive symptoms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.