ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Quantification of Antibiotic Diffusion in Biofilms Using Gold Nanostar Surface-enhanced Raman Spectroscopy.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Quantification of Antibiotic Diffusion in Biofilms Using Gold Nanostar Surface-enhanced Raman Spectroscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Emerging Multimodal Strategies for Bacterial Biofilm Eradication: A Comprehensive Review.Microorganisms · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The increased resistance to antibiotics shown by bacteria in biofilms is believed to be partly the result of the limited penetration of antibiotics. However, there are no well-established techniques which allow quantitative, label-free monitoring of antibiotic transport in biofilms. Here, it is shown that surface-enhanced Raman spectroscopy (SERS) with gold nanostars (NS) can be used for the detection of levofloxacin (Levo) in Staphylococcus aureus biofilms at clinically relevant concentrations. Ex situ studies showed that although matrix interference reduced the sensitivity compared to aqueous solutions, quantitative detection remained possible. With intact biofilms, monitoring the SERS signals from layers of NS embedded at specific depths allowed the time-dependence of the penetration of Levo from the surface to the embedded layer to be measured and the diffusion coefficient of Levo to be calculated. The measured value of D = 2.79 ± 0.79 × 10
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Registered trials
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