Evidence map›Paper›PMID 41117133›Full record

ArticleNeurodegenerative disease management

Gut microbiome differences in Parkinson's disease patients in Central Kerala population.

Anjali Anne Jacob, Sudeshna Rout, Rishikesh Dash, Giriprasad Venugopal, Ankita Ramdass Punde, John K John, Saritha Susan Varghese, Cleetus Cherupanakkal, George Chandy Mattethra, Balamurugan Ramadass

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurodegenerative disease management. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anjali Anne JacobDepartment of Microbiology, Believers Church Medical, College & Hospital (BCMCH), Thiruvalla, Kerala, India.
Sudeshna RoutDepartment of Biochemistry, All India Institute of Medical, Sciences (AIIMS), Bhubaneswar, Odisha, India.
Rishikesh DashDepartment of Biochemistry, All India Institute of Medical, Sciences (AIIMS), Bhubaneswar, Odisha, India.
Giriprasad VenugopalCentral Research Laboratory, Believers Church Medical, College & Hospital (BCMCH), Thiruvalla, Kerala, India.
Ankita Ramdass PundeCentre of Excellence for Clinical Microbiome Research (CCMR), All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, India.
John K JohnDepartment of Neurology, Believers Church Medical, College & Hospital (BCMCH), Thiruvalla, Kerala, India.
Saritha Susan VargheseDepartment of Community Medicine, Believers Church Medical, College & Hospital (BCMCH), Thiruvalla, Kerala, India.
Cleetus CherupanakkalDepartment of Biochemistry, Believers Church Medical, College & Hospital (BCMCH), Thiruvalla, Kerala, India.
George Chandy MattethraDepartment of Medical Gastroenterology & Hepatology, Believers Church Medical College & Hospital (BCMCH), Thiruvalla, Kerala, India.
Balamurugan RamadassDepartment of Biochemistry, All India Institute of Medical, Sciences (AIIMS), Bhubaneswar, Odisha, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesGut microbiota dysbiosis is increasingly implicated in Parkinson's disease (PD). This study aimed to find gut microbiota diversity and composition of PD patients in Central Kerala population, India.

methods16 PD patients were enrolled and their spouse formed the controls. Fecal Microbiome analysis was performed by 16S rRNA amplicon sequencing.

resultsSeven microbial species significantly contributed to the differences in beta diversity between the PD and control groups (

conclusionsThis study offers initial evidence for identifying PD associated gut microbiome alterations in the Kerala population to be further explored with larger and more detailed longitudinal study.

Indexed as

DysbiosisGastrointestinal MicrobiomeParkinson DiseaseAgedFecesFemaleHumansIndiaMaleMiddle AgedRNA, Ribosomal, 16SRNA, Ribosomal, 16Sbeta diversitygut-brain axisGut microbiomeParkinson’s diseaseSCFAs

Identifiers

PMID41117133
PMCPMC13192096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.