ArticleNutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition2026
Investigating demographic and geographic disparities in malnutrition and gastrointestinal cancer mortality among older adults in the United States: A comprehensive longitudinal Centers for Disease Control and Prevention WONDER analysis 1999-2020.
Article in Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Observational
- Investigating demographic and geographic disparities in malnutrition and gastrointestinal cancer mortality among older adults in the United States: A comprehensive longitudinal Centers for Disease Control and Prevention WONDER analysis 1999-2020.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026Article
- Post-COVID impairment of T cell responses to community-acquired pathogens can be modified by activating cellular metabolism.PLoS pathogens · 2026Article
- Post-COVID impairment of memory T cell responses to community-acquired pathogens can be rectified by activating cellular metabolism.bioRxiv : the preprint server for biology · 2026Article
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundMalnutrition worsens gastrointestinal (GI) cancer outcomes in older adults; long-term US mortality trends and disparities remain insufficiently understood. This study analyzed demographic/geographic mortality trends related to malnutrition and GI cancer among older adults in the United States.
methodsMortality data from 1999 to 2020 were obtained via CDC WONDER for adults aged ≥65 years, in which malnutrition and GI cancer were listed as underlying or contributing causes of death. Age-adjusted mortality rates (AAMRs) per 100,000 population and annual percentage changes (APCs) were calculated and stratified by year, sex, race/ethnicity, and region.
resultsA total of 31,806 deaths were recorded. AAMRs declined from 4.4 in 1999 to 2.6 in 2013 (APC: -7.7 to -1.4), then rose to 5.5 in 2020 (APC: 11.6, 95% CI: 10.7-12.8). Men had higher AAMRs (4.3) than women (2.7). Among men, AAMRs dropped from 5.4 in 1999 to 3.3 in 2006, then increased to 7.2 in 2020 (APC: 11.9, 95% CI: 10.5-14.1). Women's rates declined from 3.8 in 1999 to 2.0 in 2013, before rising to 4.2 in 2020 (APC: 11.8, 95% CI: 10.2-14.0). Black or African American individuals (5.3), Alaska (7.1), and the Western United States (7.0) had the highest mortality. Nonmetropolitan areas consistently had higher AAMRs (4.0) than metropolitan areas (3.3).
conclusionsAfter years of decline, mortality from malnutrition and GI cancers has sharply increased among older adults, with notable sex, racial, and regional disparities. These findings underscore the need for focused public health strategies to address these growing inequalities.
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