Evidence map›Paper›PMID 41117063›Full record

ArticleFuture medicinal chemistry2025

Thioflavonols as potent α-glucosidase inhibitors:

Ehsan Ullah Mughal, Nafeesa Naeem, Bushra Shakoor, Amina Sadiq, Muhammad Naveed Zafar, Gehan Ahmed Othman, Abdullah Y A Alzahrani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ehsan Ullah MughalDepartment of Chemistry, University of Gujrat, Gujrat, Pakistan.ORCID 0000-0001-9463-9398
Nafeesa NaeemDepartment of Chemistry, University of Gujrat, Gujrat, Pakistan.ORCID 0000-0002-6647-9697
Bushra ShakoorSynthetic & Natural Product Discovery Lab., Department of Chemistry, Government College Women University Faisalabad, Faisalabad, Pakistan.
Amina SadiqDepartment of Chemistry, Govt. College Women University, Sialkot, Pakistan.
Muhammad Naveed ZafarDepartment of Chemistry, Quaid-I-Azam University, Islamabad, Pakistan.
Gehan Ahmed OthmanBiology Department, College of Science, King Khalid University, Abha, Saudi Arabia.
Abdullah Y A AlzahraniDepartment of Chemistry, Faculty of Science, King Khalid University, Abha, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThis study investigates the inhibitory potential of a novel series of thioflavonol derivatives ( MATERIALS AND

methodsThe compounds were evaluated using

resultsSeveral derivatives exhibited strong α-glucosidase inhibition, with the most active compound significantly lowering blood glucose levels

conclusionsThis is the first comprehensive study of thioflavonols as α-glucosidase inhibitors, demonstrating their promising biological activity, stable binding behavior, and favorable pharmacokinetic properties, supporting their potential as novel anti-diabetic agents.

Indexed as

alpha-GlucosidasesGlycoside Hydrolase InhibitorsHypoglycemic AgentsAnimalsDensity Functional TheoryDiabetes Mellitus, Type 2HumansMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureStructure-Activity Relationshipalpha-GlucosidasesGlycoside Hydrolase InhibitorsHypoglycemic AgentsADMETDFTDockingIn vitroIn vivoMD SimulationSARThioflavonolsα-Glucosidase

Identifiers

PMID41117063
PMCPMC12707210

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.