ArticleGut and liver2026
Is Negative Fecal Immunochemical Test Reassuring? The Cumulative Risk of Colorectal Cancer after Multiple Negative Tests.
Article in Gut and liver, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/Aims: Colorectal cancer (CRC) risk is approximately 0.1% according to registry data, and fecal immunochemical tests (FITs) identify approximately 5% of screened individuals as positive. We evaluated whether a negative FIT result is reassuring regarding CRC risk. Methods: In this retrospective cohort study, 141,982 Taiwanese individuals aged ≥50 who underwent self-paid medical screening from 1994 to 2008 were enrolled. CRC cases and all-cause deaths were identified through the National Cancer Registry and National Death File. A negative FIT was defined as <20 μg Hb/g. Results: There were 987 CRC patients with a negative FIT and 713 with a positive FIT. Among the 133,369 individuals with one negative FIT, 113 CRC patients were registered within 2 years and 803 within 10 years; only 15% of the CRC cases were identified within the first 2 years after testing. The overall incidence was 1.27/1,000 person-years, decreasing by 63% to 0.80/1,000 person-years after one negative FIT. With repeated biennial negative FITs, CRC risk declined to 63%, 53%, 33%, 23%, and 10% over 10 years. All-cause mortality decreased from 1,106/100,000 person-years to 511/100,000 person-years. Notably, 84% of the cohort had consistently negative FIT results across all five rounds. Conclusions: Two-thirds of the 10-year CRC risk remained in individuals following one negative FIT. The risk after a negative FIT result reemerged 2 years after testing, highlighting the importance of continuing biennial FIT screening. Consistently negative FITs were associated with reduced CRC risk and a lower all-cause mortality. This study is limited by the lack of confirmatory colonoscopy in FIT-negative individuals, which may lead to an underestimation of CRC incidence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.