ReviewJournal of tropical medicine2025
Therapeutic Promises of Bioactive Linarin, a Glycosylated Flavonoid: A Comprehensive Review With Mechanistic Insight.
Review in Journal of tropical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Advancements in Technologies Targeting Horizontal Gene TransferRoutes to Control Drug Resistance Evolution.ACS bio & med chem Au · 2026Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Linarin, a flavonoid glycoside found in the Asteraceae, Lamiaceae, and Scrophulariaceae families, shows diverse therapeutic benefits in laboratory studies. This study aims to evaluate the pharmacological effects of linarin through clinical and preclinical experiments, investigating its mechanisms against different diseases. To achieve this, data collection and search operations were carried out (current as of April 09, 2024) in several reliable online databases, such as PubMed/Medline, Scopus, Springer Link, ScienceDirect, Wiley Online, Web of Science, and Google Scholar, as part of this research. Studies revealed that linarin provides benefits against inflammation and various diseases, including osteoporosis, osteoarthritis, liver injuries, diabetes, hypertension, and neurodegenerative conditions, such as Alzheimer's, ischemia-reperfusion, convulsions, and depression. Our results further reveal that linarin displays remarkable anticancer potentials through multiple molecular pathways, including apoptotic cell death, oxidative stress induction, cytotoxic effect, antiproliferative effect, genotoxic effect, and mitigation of cancer cell migration and invasion and migration against a range of malignancies, including lung, brain, prostate, and glioma cell cancers. Database reports and the current literature-based study suggest that linarin might be a prospective lead chemical for treating a range of illnesses and ailments. For linarin to be proven as a medicine, further clinical and preclinical trials are required.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.