ArticleCureus2025
Pitfalls in Coagulation Testing: A Pediatric Case of Lupus Anticoagulant Hypoprothrombinemia Syndrome Following Enterocolitis.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In children, the lupus anticoagulant (LA) is transiently produced after infection and rarely causes bleeding tendency, known as LA-hypoprothrombinemia syndrome (LAHPS). In this case report, we describe a child presenting with difficulty standing and walking after enterocolitis and complicated false coagulation abnormalities. Prolonged prothrombin time and activated partial thromboplastin time (APTT); decreased factors II, VIII, IX, XI, and XII; and inhibitors for factors VIII and IX were detected. On the basis of such findings as inhibitor pattern in the APTT cross-mixing test and positivity for serum LA, LAHPS was diagnosed. Physicians should be aware of the interference by LA with phospholipid-based coagulation tests, leading to the misinterpretation of the unusual coagulation abnormalities in LAHPS.
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