ReviewCureus2025
Impact of Age on Outcomes of Total Pancreatectomy: A Narrative Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Total pancreatectomy (TP) is a complex and rarely performed procedure. With advances in surgical techniques, perioperative care, and islet auto transplantation, TP has seen renewed clinical interest. This narrative review explores the current evidence on outcomes following TP, with a focus on age-related differences in morbidity, mortality, metabolic challenges, quality of life, and survival. Relevant literature from peer-reviewed journals was reviewed to compare perioperative and long-term outcomes in younger versus older patients undergoing TP, including the role of total pancreatectomy with islet auto transplantation (TPIAT). Although TP is associated with significant metabolic and nutritional challenges, advances in perioperative management have improved outcomes. Older patients often experience longer hospital stays and reduced long-term survival compared to younger cohorts, though age alone is not a contraindication. Islet yields in children tend to be higher, while readmission rates and postoperative recovery patterns vary between age groups. Age influences several outcome parameters following TP but should not be considered an absolute barrier to surgery. Careful patient selection, individualized metabolic support, and multidisciplinary management are critical for optimizing outcomes across all age groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.