ArticleSleep advances : a journal of the Sleep Research Society2025
Social disadvantage is associated with impaired increase in salivary diurnal melatonin amplitude throughout pregnancy.
Article in Sleep advances : a journal of the Sleep Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Study Objectives: Melatonin regulates daily rhythms and is important for maintaining a healthy pregnancy. Certain socioeconomic factors may affect melatonin release. This study evaluates whether the increase in melatonin with advancing gestation is associated with social disadvantage. Methods: Data were prospectively collected from a socioeconomically diverse cohort of participants with singleton pregnancies ( Results: Mean diurnal melatonin concentration increased at an average rate of 0.19 pg/mL/week, and amplitude increased by 0.04 pg/mL/week. Participants with high SDS had significantly lower diurnal melatonin concentration amplitudes, means, mesors, and peaks than those with low SDS. Participants with high SDS had a 2.19 [95%CI = 1.94, 2.47] adjusted relative risk for low diurnal amplitude melatonin and had a smaller increase in diurnal melatonin amplitude over weeks of pregnancy than those with low SDS (-0.04 vs. 0.11 pg/mL/week, Conclusions: Average salivary diurnal melatonin concentration increases across pregnancy, but the degree of increase varies among pregnant participants and is associated with social disadvantage.
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