Evidence map›Paper›PMID 41116823›Full record

ReviewThe Pan African medical journal2025

Multisystem inflammatory syndrome in children associated with COVID-19: a case report and literature review.

Mohamedraza Akbar Ebrahim, Shadrack Elia Makundi, Noureen Ndelimbi Mushi, Pendo Mussa Ibrahim, Rukhsar Shabir Osman, Zainab Fidaali, Deogratias Arnold Nkya

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Pan African medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mohamedraza Akbar EbrahimThe Aga Khan University, Dar es Salaam, Tanzania.
Shadrack Elia MakundiThe Aga Khan Hospital, Dar es Salaam, Tanzania.
Noureen Ndelimbi MushiThe Aga Khan Hospital, Dar es Salaam, Tanzania.
Pendo Mussa IbrahimMuhimbili University of Health and Allied Sciences Dar es Salaam, Tanzania.
Rukhsar Shabir OsmanThe Aga Khan University, Dar es Salaam, Tanzania.
Zainab FidaaliThe Aga Khan Hospital, Dar es Salaam, Tanzania.
Deogratias Arnold NkyaMuhimbili University of Health and Allied Sciences Dar es Salaam, Tanzania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Given the rarity of multisystem inflammatory syndrome related to COVID-19 (MIS-C). This case report highlights the high index of suspicion to diagnose MIS-C in a child who presented with symptoms suggestive of acute gastroenteritis. While admitted in the hospital, she deteriorated with worsening of symptoms, clinical decline, deranged laboratory markers, and significant radiological findings, even though on antibiotics. She had acute myocarditis with myocardial dysfunction on echocardiography and raised cardiac enzymes. Intravenous human immunoglobulin (IVIG) was given, but there was additional need for inotrope (norepinephrine) and methylprednisolone albeit the preliminary echocardiogram was normal. Early recognition of MIS-C with rapid escalation of care post IVIG administration is needed to prevent morbidity and mortality.

Indexed as

COVID-19Systemic Inflammatory Response SyndromeChildFemaleGastroenteritisHumansImmunoglobulins, IntravenousMethylprednisoloneMyocarditisImmunoglobulins, IntravenousMethylprednisolonecase reportCOVID-19multisystem inflammatory syndromeSevere acute respiratory syndrome coronavirus 2

Identifiers

PMID41116823
PMCPMC12535596

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.