Evidence map›Paper›PMID 41116758›Full record

ArticleThe Plant journal : for cell and molecular biology2025

A new tool for engineering Phaeodactylum tricornutum: the METE promoter drives both high expression and B

Patrick R Hickland, Katrin Geisler, Shelby Newsad, Marcel Llavero Pasquina, A Caroline Faessler, Gonzalo I Mendoza-Ochoa, Andre Holzer, Payam Mehrshahi, Alison G Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Plant journal : for cell and molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Special Issue "Microalgal Molecules and Enzymes 2.0".International journal of molecular sciences · 2026
    Article
  2. Marine drugs · 2026
    Review
  3. Article
  4. Harnessing microalgae for bioproducts: innovations in synthetic biology.World journal of microbiology & biotechnology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Patrick R HicklandDepartment of Plant Sciences, University of Cambridge, Downing Street, Cambridge, CB2 3EA, UK.ORCID 0009-0008-5880-7719
Katrin GeislerDepartment of Plant Sciences, University of Cambridge, Downing Street, Cambridge, CB2 3EA, UK.ORCID 0000-0002-7630-1868
Shelby NewsadDepartment of Plant Sciences, University of Cambridge, Downing Street, Cambridge, CB2 3EA, UK.ORCID 0000-0001-6149-8111
Marcel Llavero PasquinaDepartment of Plant Sciences, University of Cambridge, Downing Street, Cambridge, CB2 3EA, UK.ORCID 0000-0002-7055-0812
A Caroline FaesslerDepartment of Plant Sciences, University of Cambridge, Downing Street, Cambridge, CB2 3EA, UK.ORCID 0000-0003-1256-3444
Gonzalo I Mendoza-OchoaDepartment of Plant Sciences, University of Cambridge, Downing Street, Cambridge, CB2 3EA, UK.ORCID 0000-0002-7361-8915
Andre HolzerDepartment of Plant Sciences, University of Cambridge, Downing Street, Cambridge, CB2 3EA, UK.ORCID 0000-0003-2439-6364
Payam MehrshahiDepartment of Plant Sciences, University of Cambridge, Downing Street, Cambridge, CB2 3EA, UK.ORCID 0000-0002-7192-0942
Alison G SmithDepartment of Plant Sciences, University of Cambridge, Downing Street, Cambridge, CB2 3EA, UK.ORCID 0000-0001-6511-5704

Funding

Algenuity LtdBill and Melinda Gates Foundation OPP1144Biotechnology and Biological Sciences Research Council BB/L002957/1Biotechnology and Biological Sciences Research Council BB/L014130/1Biotechnology and Biological Sciences Research Council BB/M011194/1Biotechnology and Biological Sciences Research Council BB/M018180/1Biotechnology and Biological Sciences Research Council BB/R021694/1University of Cambridge
6 · The paper itself

Abstract

For advanced metabolic engineering strategies, it is crucial to be able to regulate transgene expression, to prevent potential deleterious effects in the host organism during growth and allow optimisation of production levels. Here, we identified vitamin B

Indexed as

5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseDiatomsMetabolic EngineeringPromoter Regions, GeneticTransgenesVitamin B 125-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseVitamin B 12diterpeneenhancer motifmetabolic engineeringmethionine synthasemicroalgaePhaeodactylum tricornutumtuneable promotervitamin B12

Identifiers

PMID41116758
PMCPMC12538271

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.