Evidence map›Paper›PMID 41116750›Full record

ArticleAging cell2025

An Ad Libitum-Fed Diet That Matches the Beneficial Lifespan Effects of Caloric Restriction but Acts via Opposite Effects on the Energy-Splicing Axis.

Amanda E Brandon, Tamara Pulpitel, Carsten Schmitz-Peiffer, Lewin Small, Alistair M Senior, Sophie Stonehouse, Letisha Prescott, Alyssa Face, K Saiful Islam, Jenny E Gunton and 5 more

Erratum issuedAbstract read
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In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Amanda E BrandonCharles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
Tamara PulpitelCharles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
Carsten Schmitz-PeifferCharles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
Lewin SmallCharles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
Alistair M SeniorCharles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
Sophie StonehouseCharles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
Letisha PrescottCharles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
Alyssa FaceCharles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
K Saiful IslamCharles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
Jenny E GuntonDepartment of Diabetes and Endocrinology, Westmead Hospital, Sydney, New South Wales, Australia.
Jacob GeorgeStorr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital, Sydney, New South Wales, Australia.
David RaubenheimerCharles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
Gregory J CooneyCharles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
David G Le CouteurCharles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-4227-5817
Stephen J SimpsonCharles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.

Funding

National Health and Medical Research Council 1149976National Health and Medical Research Council 2025511
6 · The paper itself

Abstract

Caloric restriction (CR) with fasting extends lifespan but is difficult to maintain in humans. Here, we compared conventional CR with periods of fasting to an ad libitum-fed low-protein, high-carbohydrate (LPHC) diet diluted 25% with non-digestible fibre. Both approaches similarly enhanced longevity and metabolic health in mice relative to a control diet. Proteomic analysis of liver tissue revealed that CR increased proteins associated with energy and mitochondrial pathways. By contrast, the LPHC diet reduced these pathways but increased the abundance of proteins associated with RNA metabolism and spliceosome pathways. These results for LPHC support the "energy-splicing resilience" axis theory of ageing. Our results suggest that ad libitum-fed diets can be designed to replicate, and potentially enhance, the geroprotective benefits of CR, albeit via different mechanisms, potentially offering a more sustainable dietary approach to longevity extension.

Indexed as

Caloric RestrictionDietEnergy MetabolismLongevityRNA SplicingAnimalsLiverMaleMiceMice, Inbred C57BLageinglifespanlivernutritionproteomics

Identifiers

PMID41116750
PMCPMC12686583

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.