Evidence map›Paper›PMID 41116724›Full record

ArticleJournal of the International Neuropsychological Society : JINS2025

Everyday functioning in treatment-resistant late-life depression: The mediating role of cognition.

Ashlyn Runk, Katrail Davis, Hannah Lovato, Peter Zhukovsky, Meryl A Butters, Aristotle Voineskos, Helen Lavretsky, Joshua S Shimony, Patrick Brown, Matthew Calamia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ashlyn Runkhttps://ror.org/05ect4e57Louisiana State University, Department of Psychology, Baton Rouge, LA, USA.ORCID https://orcid.org/0009-0004-1287-671X
Katrail Davishttps://ror.org/05ect4e57Louisiana State University, Department of Psychology, Baton Rouge, LA, USA.
Hannah Lovatohttps://ror.org/05ect4e57Louisiana State University, Department of Psychology, Baton Rouge, LA, USA.
Peter ZhukovskyCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health & Department of Psychiatry, University of Toronto, Toronto, Canada.
Meryl A ButtersUniversity of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, USA.
Aristotle VoineskosCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health & Department of Psychiatry, University of Toronto, Toronto, Canada.
Helen LavretskyUniversity of California - Los Angeles, Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, USA.
Joshua S ShimonyWashington University School of Medicine, Department of Radiology, St. Louis, MO, USA.
Patrick BrownColumbia University, Department of Psychiatry, New York, NY, USA.
Matthew Calamiahttps://ror.org/05ect4e57Louisiana State University, Department of Psychology, Baton Rouge, LA, USA.ORCID https://orcid.org/0000-0002-7252-7181

Funding

1/4-Deciphering Mechanisms of ECT Outcomes and Adverse Effects (DECODE)R01MH128690 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Katherine L Narr · 2022 to 2026
$2.9M
3/5 Neurocognitive and neuroimaging biomarkers: predicting progression towards dementia in patients with treatment resistant late-life depressionR01MH114969 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BUTTERS, MERYL A · 2017 to 2021
$2.6M
1/5 Neurocognitive and neuroimaging biomarkers: predicting progression towards dementia in patients with treatment-resistant late-life depressionR01MH114970 · NIMH · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI VOINESKOS, ARISTOTLE NICHOLAS · 2017 to 2021
$2.0M
2/5 Neurocognitive and neuroimaging biomarkers: predicting progression towards dementia in patients with treatment resistant late-life depression.R01MH114980 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BROWN, PATRICK J, RUTHERFORD, BRET R · 2017 to 2021
$1.8M
4/5 Neurocognitive and neuroimaging biomarkers: predicting progression towards dementia in late-life depressionR01MH114981 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAVRETSKY, HELEN, NARR, KATHERINE L · 2017 to 2021
$1.8M
5/5 Neurocognitive and neuroimaging biomarkers: predicting progression toward dementia in patients with treatment resistant late-life depressionR01MH114966 · NIMH · WASHINGTON UNIVERSITY · PI SHIMONY, JOSHUA S · 2017 to 2021
$1.7M
NIMH NIH HHS R01 MH114966NIMH NIH HHS R01 MH114969NIMH NIH HHS R01 MH114970NIMH NIH HHS R01 MH114980NIMH NIH HHS R01 MH114981NIMH NIH HHS R01 MH128690
6 · The paper itself

Abstract

objectiveEveryday functional capacity in older adults is influenced by several factors, with prior studies finding that cognition mediates the relationship between depression and everyday functioning. However, these studies utilized samples with low depression severity and used only one type of functional assessment. We aimed to examine whether cognition mediates the relationship between depression and functioning in older adults with a history of treatment-resistant depression.

methodData from 383 participants enrolled in the OPTIMUM Neuro study were analyzed. Participants completed a neuropsychological assessment battery, depression severity interview, self-/informant-rated functioning measures and a performance-based functioning measure. Linear regression was used to determine whether depression scores predicted cognitive domain and everyday functioning scores. Cognitive domain scores predicted by depression were then tested as mediators between depression and functioning.

resultsHigher depression symptoms predicted poorer performance on all measures of functioning as well as the cognitive domains of attention, executive functioning, and immediate memory. Immediate memory partially mediated the relationship between depression and a performance-based measure of functioning, while attention and executive functioning partially mediated the relationship between a self-report measure of functioning and depression.

conclusionsThe relationship between depression severity and poorer functional performance was partially mediated by attention, executive functioning, and immediate memory, with results differing based on the measure of functioning used. Our findings suggest that there may be additional non-cognitive factors influencing this relationship and highlight the importance of using multiple methods to assess functional performance.

Indexed as

Activities of Daily LivingAgingDepressive Disorder, Treatment-ResistantExecutive FunctionAgedAged, 80 and overAttentionFemaleHumansMaleMemory, Short-TermMiddle AgedNeuropsychological TestsSeverity of Illness IndexCognitive FunctioningDepressive SymptomsFunctional PerformanceGeriatric PsychiatryInstrumental Activities of Daily LivingOlder Adults

Identifiers

PMID41116724
PMCPMC12614437

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.